Results 91 to 100 of about 195,033 (294)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Learning and communication pressures in neural networks: Lessons from emergent communication

Language Development Research
Finding and facilitating commonalities between the linguistic behaviors of large language models and humans could lead to major breakthroughs in our understanding of the acquisition, processing, and evolution of language.
Limor Raviv, Lukas Paul Achatius Galke
doaj   +2 more sources

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Cultural evolution leads to vocal iconicity in an experimental iterated learning task [Elektronisk resurs]

, 2021
Experimental and cross-linguistic studies have shown that vocal iconicity is prevalent in words that carry meanings related to size and shape. Although these studies demonstrate the importance of vocal iconicity and reveal the cognitive biases ...
Kirby, Simon,, Erben Johansson, Niklas,, Carr, Jon W.,, Lund University.   +3 more
core   +1 more source

A universal preference for animate agents in hominids

iScience
Summary: When conversing, humans instantaneously predict meaning from fragmentary and ambiguous mspeech, long before utterance completion. They do this by integrating priors (initial assumptions about the world) with contextual evidence to rapidly decide
Sarah Brocard, Vanessa A.D. Wilson, Chloé Berton, Klaus Zuberbühler, Balthasar Bickel   +4 more
doaj   +1 more source

Editorial: Challenges in language evolution research. [PDF]

Front Psychol, 2023
Mineiro A.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Categorical perception and language evolution: a comparative and neurological perspective. [PDF]

Front Psychol, 2023
Zhang EQ, Shi ER, Barceló-Coblijn L.
europepmc   +1 more source

Evolution of Language Interpreters

Electronic Notes in Theoretical Computer Science, 2005
AbstractWe are interested in evolution scenarios for language-based functionality. We identify different dimensions along which such functionality can evolve, including the following: (i) coding style; (ii) coding details; (iii) data model; (iv) crosscutting concerns; and (v) patches.
openaire   +1 more source