Results 71 to 80 of about 6,114,820 (273)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Linguistic pitch is hierarchically encoded in the right ventral stream
Communications BiologyA challenge for speech perception research is to explain how listeners transform speech sounds into meaning. Using MEG and complementary analytical methods, we expose the neural dynamics that generate meaningful linguistic units (e.g., sentence type ...
Chantal Oderbolz +2 more
doaj +1 more source
Polysemy and metaphorical extension in an artificial language learning experiment
Language and CognitionThis study investigates the emergence of metaphorical meanings in abstract visual symbols within an ‘alien language’ artificial language learning game. Findings reveal that participants extend concrete meanings to abstract meanings based on metaphorical ...
Michael Pleyer +2 more
doaj +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Why language really is not a communication system
Frontiers in Psychology, 2015 While most evolutionary scenarios for language see it as a communication system with consequences on the language-ready brain, there are major difficulties for such a view. First, language has a core combination of features—semanticity, discrete infinity,
Anne Colette Reboul
doaj +1 more source
A complex systems perspective on language evolution
Language is acknowledged as a complex adaptive system, but its implications from a modelingperspective remain largely under-explored. This paper explores the application of complex systems theory, as formalized by Thurner, Hanel, and Klimek in their book,
Michaud, Jérôme, Michaud, Jérôme,
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
The evolution of language and languages
, 1998 Human languages, such as French, Cantonese or American Sign Language, are socio- cultural entities. Knowledge of them (`competence') is acquired by exposure to the ap- propriate environment. Languages are maintained and transmitted by acts of speaking and writing; and this is also the means by which languages evolve.
openaire +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source