Results 71 to 80 of about 1,502,462 (293)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Linguistic pitch is hierarchically encoded in the right ventral stream
Communications BiologyA challenge for speech perception research is to explain how listeners transform speech sounds into meaning. Using MEG and complementary analytical methods, we expose the neural dynamics that generate meaningful linguistic units (e.g., sentence type ...
Chantal Oderbolz +2 more
doaj +1 more source
Language Evolution and Music Evolution
Together with language, music is perhaps the most distinctive behavioral trait of our species. Different hypotheses have been proposed to explain why only humans speak and why only they perform music and, if both abilities are evolutionary related, how and why they eventually diverged. Human linguisticality and musicality are certainly biologically and
Antonio Benítez-Burraco +1 more
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
From elite to subaltern : stages in the adoption of the English language in India [PDF]
, 2012 Probal Dasgupta, in his book, 'The Otherness of English', posits that "the communication matrix of India identifies for English in-India the role of an "auntie" who is around, but not one of us." Despite early reservations about the adaptability of the ...
Cowaloosur, Vedita
core
Monte Carlo simulation of the rise and the fall of languages
, 2004 Similar to biological evolution and speciation we define a language through a string of 8 or 16 bits. The parent gives its language to its children, apart from a random mutation from zero to one or from one to zero; initially all bits are zero.
Schulze, Christian, Stauffer, Dietrich
core +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
The Quantum Gauge Principle [PDF]
, 1996 We consider the evolution of quantum fields on a classical background space-time, formulated in the language of differential geometry. Time evolution along the worldlines of observers is described by parallel transport operators in an infinite ...
Graudenz, Dirk
core +1 more source
Fixation and consensus times on a network: a unified approach
, 2008 We investigate a set of stochastic models of biodiversity, population genetics, language evolution and opinion dynamics on a network within a common framework. Each node has a state, 0 < x_i < 1, with interactions specified by strengths m_{ij}.
A. J. McKane +9 more
core +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source