Results 51 to 60 of about 64,480 (260)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Bosnian/Croatian/Serbian Heritage Speakers in Four Major U.S. Metropolitan Areas: Resources for the Attainment of Full Professional Linguistic Proficiency

East/West: Journal of Ukrainian Studies, 2017
The present study analyzes heritage learners of Bosnian/Croatian/Serbian (BCS) from four major U.S. metropolitan areas. The focus is on the prospects of their attaining full professional language proficiency. Several major factors in language maintenance
Danko Šipka
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

THE INFLUENCE OF STUDENT BACKGROUND CHARACTERISTICS ON PROFICIENCY IN ENGLISH AS A FOREIGN LANGUAGE: INDONESIAN CONTEXT

Jurnal Sosial Humaniora, 2017
In order to explain differences in English proficiency level, one needs to consider a number of factors frequently considered important at a variety of level of education systems.
Ratna Rintaningrum, Carol Aldous, John P Keeves   +2 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

A Foreign Language Effect or a Language Proficiency Effect? [PDF]

, 2015
Recent work suggests that people think more systematically when using a second language because second languages are less automatic or emotionally valenced. Here, we use a different population (from India) to further investigate this possibility. We also test whether nuanced factors like language proficiency, usage context, and age of acquisition ...
Thibodeau, Paul, Kalafus-Mastenbrook, Evelyn, Berretta, Matias, Tuzhilin, Aliya, Agrawal, Nupur   +4 more
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Bilingual Language Proficiency. A Comparative Study

, 2011
This book investigates the role native language plays in the process of acquiring a second language within a bilingual educational model. The research presented is based on a 2-year longitudinal study of students in a bilingual school. Particular attention is paid to the development of academic language proficiency.
openaire   +3 more sources

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

On A Possible Relationship between Linguistic Expertise and EEG Gamma Band Phase Synchrony

Frontiers in Psychology, 2011
Recent research has shown that extensive training in and exposure to a second language can modify the language organization in the brain by causing both structural and functional changes.
Susanne Maria Reiterer, Susanne Maria Reiterer, Susanne Maria Reiterer, Ernesto ePereda, Joydeep eBhattacharya, Joydeep eBhattacharya   +5 more
doaj   +1 more source