Results 51 to 60 of about 68,883 (263)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Language learning bridge: how translation and interpreting training impacts bilingual proficiency in heritage and L2 learners

Frontiers in Education
IntroductionTranslation and interpreting training offers a promising context for advancing bilingual proficiency, integrating skill development while bridging second language acquisition and translation studies.
Cristina Lozano-Argüelles, Aída Martínez-Gómez   +1 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

A Foreign Language Effect or a Language Proficiency Effect? [PDF]

, 2015
Recent work suggests that people think more systematically when using a second language because second languages are less automatic or emotionally valenced. Here, we use a different population (from India) to further investigate this possibility. We also test whether nuanced factors like language proficiency, usage context, and age of acquisition ...
Thibodeau, Paul, Kalafus-Mastenbrook, Evelyn, Berretta, Matias, Tuzhilin, Aliya, Agrawal, Nupur   +4 more
openaire   +1 more source

Bosnian/Croatian/Serbian Heritage Speakers in Four Major U.S. Metropolitan Areas: Resources for the Attainment of Full Professional Linguistic Proficiency

East/West: Journal of Ukrainian Studies, 2017
The present study analyzes heritage learners of Bosnian/Croatian/Serbian (BCS) from four major U.S. metropolitan areas. The focus is on the prospects of their attaining full professional language proficiency. Several major factors in language maintenance
Danko Šipka
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Bilingual Language Proficiency. A Comparative Study

, 2011
This book investigates the role native language plays in the process of acquiring a second language within a bilingual educational model. The research presented is based on a 2-year longitudinal study of students in a bilingual school. Particular attention is paid to the development of academic language proficiency.
openaire   +3 more sources

THE INFLUENCE OF STUDENT BACKGROUND CHARACTERISTICS ON PROFICIENCY IN ENGLISH AS A FOREIGN LANGUAGE: INDONESIAN CONTEXT

Jurnal Sosial Humaniora, 2017
In order to explain differences in English proficiency level, one needs to consider a number of factors frequently considered important at a variety of level of education systems.
Ratna Rintaningrum, Carol Aldous, John P Keeves   +2 more
doaj   +1 more source