Results 71 to 80 of about 68,883 (263)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Deconstructing the Discourse of Proficiency: Social Class and Preservice English Language Teachers

Profile: Issues in Teachers' Professional Development
The discourse of proficiency in English-language teacher education has been shaped by corporate demands for an ideal speaker. This discourse forces future English language teachers to meet rigid expectations that overlook their sociocultural traits, such
Jhooni Albeiro Quintero-González, Jose David Largo-Rodriguez, Adriana Castañeda-Londoño   +2 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

MOTIVATION AND LEARNING STYLE: DO THEY CORRELATE WITH LANGUAGE PROFICIENCY?

ELT Echo: The Journal of English Language Teaching in Foreign Language Context, 2019
This paper discusses the issues of motivational orientation, learner types and their relationship with English Language Proficiency among the students of semester one in the academic year 2018 / 2019 at the State Institute of Islamic Studies Syekh ...
Udin Kamiludin
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Cognitive Mechanisms of Referential Ambiguity Resolution in L2 Russian by Chinese Learners: Evidence from Eye-Tracking

Journal of Eye Movement Research
A central question in second language (L2) sentence processing concerns how learners resolve referential ambiguity in real time, particularly when cues from their first language (L1) conflict with those of the target language.
Tian Ran, Lijun Guo, Hong Xu
doaj   +1 more source

A critical discourse analysis of the reasons underlying Arab student-teachers’ inadequate English language proficiency

Cogent Education, 2017
Despite the emphasis laid on demonstrating English language proficiency by Non-Native English Speaking Teachers (NNESTs), research has shown that for various reasons English language teachers graduating from a state-owned university in an Arab country ...
Ali S.M. Al-Issa, Ali Hussain Al-Bulushi, Rima Mansoor Al-Zadjali   +2 more
doaj   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Foreign language comprehension achievement: insights from the cognate facilitation effect

Frontiers in Psychology, 2015
Numerous studies have shown that the native language influences foreign word recognition and that this influence is modulated by the proficiency in the nonnative language.
Aina eCasaponsa, Eneko eAntón, Alejandro ePérez, Jon Andoni eDunabeitia   +3 more
doaj   +1 more source