Results 41 to 50 of about 18,195 (260)

Comparative analysis of the effect of PO administered acid suppressants on gastric pH in healthy cats

Journal of Veterinary Internal Medicine, 2020
Background Proton pump inhibitors (PPIs) are among the most commonly prescribed medications for esophagitis and upper gastrointestinal erosion and ulceration in cats.
Phillip Ryan, Adesola Odunayo, Josh Price, Silke Hecht, Shanna Hillsman, Gina Galyon, Joerg Steiner, M. Katherine Tolbert   +7 more
doaj   +1 more source

Pharmacokinetic Study and Incurred Sample Stability of Esomeprazole in Dried Blood Spot Sample Using High Performance Liquid Chromatography-Photodiode Array

Indonesian Journal of Chemistry, 2020
In the past years, Esomeprazole (EMP) was analyzed in human plasma samples, which still has stability issues; thus, the new biosampling technique known as Dried Blood Spot (DBS) might solve the issue.
Yahdiana Harahap, Anja Tamabri, Vicha Vicha, Herman Suryadi, Sunarsih Sunarsih, Callista Andinie Mulyadi   +5 more
doaj   +1 more source

Lansoprazole Alone or in Combination With Gefitinib Shows Antitumor Activity Against Non-small Cell Lung Cancer A549 Cells in vitro and in vivo

Frontiers in Cell and Developmental Biology, 2021
Lansoprazole (Lpz) is an FDA-approved proton pump inhibitor (PPI) drug for the therapy of acid-related diseases. Aiming to explore the new application of old drugs, we recently investigated the antitumor effect of Lpz.
Xiaoxia Zhao, Ning Zhang, Yingying Huang, Xiaojing Dou, Xiaolin Peng, Wei Wang, Zhe Zhang, Ran Wang, Yuling Qiu, Meihua Jin, Dexin Kong, Dexin Kong   +11 more
doaj   +1 more source

PRIMMO study protocol : a phase II study combining PD-1 blockade, radiation and immunomodulation to tackle cervical and uterine cancer [PDF]

, 2019
Background: Immunotherapeutic approaches have revolutionized oncological practice but are less evaluated in gynecological malignancies. PD-1/PD-L1 blockade in gynecological cancers showed objective responses in 13-17% of patients.
Amant, Frédéric, Aspeslagh, Sandrine, De Caluwé, Alex, De Jaeghere, Emiel, Denys, Hannelore, Dirix, Piet, Lippens, Lien, Naert, Eline, Tuyaerts, Sandra, Van Dam, Peter A, Van Nuffel, An MT, Vandecasteele, Katrien, Vuylsteke, Peter   +12 more
core   +1 more source

Lansoprazole-induced osteoporosis via the IP3R- and SOCE-mediated calcium signaling pathways

Molecular Medicine, 2022
Background Many clinical studies have shown a correlation between proton pump inhibitors (PPIs) and osteoporosis or fractures. The purpose of this study was to establish a murine model of chronic oral PPI administration to verify whether PPIs caused bone
Ziping Cheng, Yangjie Liu, Mengyuan Ma, Shiyu Sun, Zengqing Ma, Yu Wang, Liyuan Yu, Xuping Qian, Luning Sun, Xuehui Zhang, Yun Liu, Yongqing Wang   +11 more
doaj   +1 more source

Application of Metal‐Organic Framework Composites

ChemistryEurope, EarlyView.
This review summarizes the applications of MOF composites in adsorption, energy storage, catalysis, biomedicine, and sensing. It also discusses the functionality of MOF composites from a dimensional perspective. Environmental issues have intensified, and demand for energy continues to grow, making it challenging for conventional materials to meet the ...
Yihao Chen, Hengyue Xu, Jiakang Shi, Yichun Su, Xudong Chen, Huan Pang   +5 more
wiley   +1 more source

Review article: the global emergence of Helicobacter pylori antibiotic resistance. [PDF]

, 2016
BackgroundHelicobacter pylori is one of the most prevalent global pathogens and can lead to gastrointestinal disease including peptic ulcers, gastric marginal zone lymphoma and gastric carcinoma.AimTo review recent trends in H.
Aramin, H, Crowe, SE, Gupta, S, Park, JY, Thung, I, Valasek, MA, Vavinskaya, V   +6 more
core   +1 more source

Local sensitivity analysis of a supercritical extraction model

The Canadian Journal of Chemical Engineering, EarlyView.
Abstract This study investigates the process of chamomile oil extraction from chamomile flowers. A parameter‐distributed model, consisting of a set of partial differential equations, was used to describe the governing mass transfer phenomena between solid and fluid phases under supercritical conditions using carbon dioxide as the solvent.
Oliwer Sliczniuk, Pekka Oinas
wiley   +1 more source

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

Bacterial-derived Polymer Poly-y-Glutamic Acid (y-PGA)-based micro/nanoparticles as a delivery system for antimicrobials and other biomedical applications [PDF]

, 2017
: In the past decade, poly-γ-glutamic acid (γ-PGA)-based micro/nanoparticles have garnered remarkable attention as antimicrobial agents and for drug delivery, owing to their controlled and sustained-release properties, low toxicity, as well as ...
Adamus, Grazyna, Burns, Alan, Johnston, Brian, Khalaf, Tamara, Khalil, Ibrahim, Khechara, Martin, Kowalczuk, Marek, Radecka, Iza   +7 more
core   +2 more sources