Results 221 to 230 of about 6,528 (248)

Pinensins: The First Antifungal Lantibiotics

Angewandte Chemie International Edition, 2015
AbstractLantibiotics (lanthionine‐containing antibiotics) from Gram‐positive bacteria typically exhibit activity against Gram‐positive bacteria. The activity and structure of pinensin A (1) and B (2), lantibiotics isolated from a native Gram‐negative producer Chitinophaga pinensis are described.
Kathrin I, Mohr, Carsten, Volz, Rolf, Jansen, Victor, Wray, Judith, Hoffmann, Steffen, Bernecker, Joachim, Wink, Klaus, Gerth, Marc, Stadler, Rolf, Müller   +9 more
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Post-translational modifications of lantibiotics

Antonie van Leeuwenhoek, 1996
Several newly reported post-translational modification reactions are involved in lantibiotic biosynthesis. A short overview of the present knowledge on the post-translational modifications and on the enzymes involved in lantibiotic biosynthesis is given. The oxidative decarboxylation of the epidermin precursor peptide EpiA is described in detail.
T, Kupke, F, Götz
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Lantibiotic Production by Pathogenic Microorganisms

Current Protein & Peptide Science, 2012
Lantibiotics are ribosomally synthesised, post-translationally modified antimicrobial peptides produced by Gram positive bacteria, many which have broad-ranging antimicrobial activities. Lantibiotics have long been the subject of investigation with a view to their application as food preservatives or chemotherapeutic agents for clinical and veterinary ...
Karen M, Daly, Paul D, Cotter, Colin, Hill, R Paul, Ross   +3 more
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The genetics of lantibiotic biosynthesis

BioEssays, 1995
AbstractThe lantibiotics are a rapidly expanding group of biologically active peptides produced by a variety of Gram‐positive bacteria, and are so‐called because of their content of the thioether amino acids lanthionine and β‐methyllanthionine. These amino acids, and indeed a number of other unusual amino acids found in the lantibiotics, arise ...
R, Jack, G, Bierbaum, C, Heidrich, H G, Sahl   +3 more
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Discovery of Medically Significant Lantibiotics

Current Drug Discovery Technologies, 2009
The emergence of drug-resistant pathogens such as staphylococci and enterococci in the hospital setting has long being recognized as a serious clinical problem. Staphylococcus aureus is the causative agent of many nosocomial infections from minor skin abscesses to serious, potentially life threatening diseases such as bone and soft tissue intra ...
Clare, Piper, Paul D, Cotter, R Paul, Ross, Colin, Hill   +3 more
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Structure Revision of the Lantibiotic 97518

Journal of Natural Products, 2009
The lantibiotic 97518, produced by a Planomonospora sp., was reported as a 2194 Da polypeptide comprising 24 amino acid residues with five thioether bridges. It was assigned to the mersacidin subgroup of type B lantibiotics by Castiglione et al. (Biochemistry 2007, 46, 5884-5897) and named planosporicin.
MAFFIOLI, SONIA ILARIA, D. Potenza, F. Vasile, M. De Matteo, M. Sosio, B. Marsiglia, V. Rizzo, C. Scolastico, S. Donadio   +8 more
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Combination of Antibiotic Mechanisms in Lantibiotics

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Anja, Hoffmann, Ulrike, Pag, Imke, Wiedemann, Hans-Georg, Sahl   +3 more
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Novel lantibiotics and their pre-peptides

Antonie van Leeuwenhoek, 1996
In recent years there has been a considerable increase in studies of bactericidal peptides produced by Gram-positive bacteria, with particular emphasis upon their potential application as food preservatives. A number of these peptides contain lanthionine and other post-translationally modified amino acid residues.
I F, Nes, J R, Tagg
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Structures of lantibiotics studied by NMR

Antonie van Leeuwenhoek, 1996
During the last decade, Nuclear Magnetic Resonance has played an important role in the unravelling of the primary and tertiary structures of lantibiotics. A short overview of these studies, together with typical spatial structures obtained, is presented.
F J, van De Ven, G, Jung
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[Lantibiotics].

Bacteriologia, virusologia, parazitologia, epidemiologia (Bucharest, Romania : 1990), 1993
Lantibiotics synthesized by gram positive bacteria (Staphylococcus, Streptococcus, Bacillus, genera) are a special group of polycyclic polypeptides constituted of protein amino acids and unusual amino acids (i.e. lanthionine, beta-methyllantionine etc.) these last ones exhibiting interchain thioeter bridges and ring structures.
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