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Post-translational modifications during lantibiotic biosynthesis
Current Opinion in Chemical Biology, 2004Recent reports have provided the first insights into the mechanisms of the extensive post-translational modifications involved in the biosynthesis of the lantibiotics, a class of peptide antimicrobial agents. These modifications involve dehydration of several serine and threonine residues followed by intramolecular conjugate additions of cysteines ...
Lili, Xie, Wilfred A, van der Donk
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Two-Peptide Lantibiotics: A Medical Perspective
Mini-Reviews in Medicinal Chemistry, 2007Lantibiotics are ribosomally synthesised, post-translationally modified antimicrobial peptides that exhibit activity against a wide-range of Gram positive bacteria. During the last decade a number of two-peptide lantibiotics, i.e. lantibiotics that function optimally as a consequence of the synergistic activity of two peptides, have been identified ...
Elaine M, Lawton +3 more
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Genetic Engineering of Lantibiotics
1998In contrast to “classical” peptide antibiotics, lantibiotics are gene encoded pep-tides and, therefore, the modification of the peptide structure, i.e., the exchange of single amino acids by site-directed mutagenesis of the structural gene lanA, is possible.
Ralph W. Jack +2 more
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