Results 91 to 100 of about 10,828,663 (311)

Halide gas-phase-doping technique to fabricate large-mode-area laser fiber

, 2016
By using rare;earth;halide gas;phase;doping technique, we fabricated Yb;doped large;mode;area fiber preform. Yb concentration is of ∼9500ppmw in core area and 951W@1064nm laser output was obtained with a slope efficiency of 83.3%.
Zhan, Huan, Wang, Jianjun, Gao, Cong, Peng, Kun, Wang, Zhen, Ni, Li, Lin, Aoxiang, Jing, Feng, Wang, Yuying, Lin, Aoxiang (aoxiang.research@gmail.com)   +9 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Anti-Resonant Fiber with Large Mode Area and Ultra-High HOMER for Near-Infrared High-Power Laser

Photonics
A novel anti-resonant hollow-core fiber (AR-HCF) is proposed. The fiber uses cross-nested circular cladding tubes including single-nested and non-nested tubes in the near-infrared spectral region of 1.3–1.7 μm.
Shuyi Wang, Guangrong Sun, Meng Wang, Linyong Yang, Yangweinan Cai, Jing Shi, Peicong Liu, Zhiyue Zhou, Zilun Chen, Zefeng Wang   +9 more
doaj   +1 more source

Spectral characteristics of chirped fiber Bragg gratings in large-mode-area fibers

, 2011
A matrix method is extended to solve the multimode coupling differential equations, and thereby the spectral characteristics of the chirped Bragg gratings in large-mode-area fibers (LMA FBGs) are studied theoretically.
ZhaoBaoyin, ZhaoWei, DuanKailiang, Zhao Baoyin   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Pedoman Pengelolaan Penelitian Universitas Medan Area [PDF]

, 2020
32 HalamanAssalaamu’alaikum warohmatulloohi wabarokaatuh, Puji syukur ke hadirat Allah SWT yang telah melimpahkan segala nikmat sehingga buku Pedoman Pengelolaan Penelitian Universitas Medan Area ini dapat diselesaikan.
Universitas Medan Area, Lembaga Penelitian dan Pengabdian Kepada Masyarakat
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Design of Mixed-mode Readout Electronics for Large-area SiPM Arrays

Yuanzineng kexue jishu
Accurate localization of radioactive material is essential for finding “orphan sources”, decontaminating and decommissioning nuclear facilities, and optimizing radiation protection.
HE Lei1, 2, ZHAO Xiuliang1, , HUANG Yuefeng2, HOU Huiliang2, 3, AN Kunhao2, 3
doaj   +1 more source

Mode-adaptive control of a kilowatt-level large-mode-area fiber laser based on 5×1 photonic lantern

High Power Laser Science and Engineering
This study presents high-power mode-selective operation in a large-mode-area (LMA) fiber laser. A spatial mode-adaptive control system incorporating a 5×1 photonic lantern was employed to facilitate mode conversion between the LP01 and LP11 modes.
Wenguang Liu, Yanyang Hu, Hanwei Zhang, Lianchuang Ding, Pengfei Liu, Baozhu Yan, Jiangbin Zhang, Qiong Zhou, Zongfu Jiang   +8 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source