Results 81 to 90 of about 2,796,396 (258)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Design of Mixed-mode Readout Electronics for Large-area SiPM Arrays

Yuanzineng kexue jishu
Accurate localization of radioactive material is essential for finding “orphan sources”, decontaminating and decommissioning nuclear facilities, and optimizing radiation protection.
HE Lei1, 2, ZHAO Xiuliang1, , HUANG Yuefeng2, HOU Huiliang2, 3, AN Kunhao2, 3
doaj   +1 more source

Mode-adaptive control of a kilowatt-level large-mode-area fiber laser based on 5×1 photonic lantern

High Power Laser Science and Engineering
This study presents high-power mode-selective operation in a large-mode-area (LMA) fiber laser. A spatial mode-adaptive control system incorporating a 5×1 photonic lantern was employed to facilitate mode conversion between the LP01 and LP11 modes.
Wenguang Liu, Yanyang Hu, Hanwei Zhang, Lianchuang Ding, Pengfei Liu, Baozhu Yan, Jiangbin Zhang, Qiong Zhou, Zongfu Jiang   +8 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

High energy, 1572.3 nm pulses for CO2 LIDAR from a polarization-maintaining, very-large-mode-area, Er-doped fiber amplifier.

Optics Express, 2016
We demonstrate the first polarization-maintaining, very-large-mode-area, Er-doped fiber amplifier with ~1100 μm2 effective area. The amplifier is core pumped by a Raman fiber laser and is used to generate single-frequency, one-microsecond, pulses with ...
J. W. Nicholson, Anthony DeSantolo, M.-F. Yan, Patrick W. Wisk, Brian Joseph Mangan, G. Puc, Anthony W. Yu, M. Stephen   +7 more
semanticscholar   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Large on-chip Brillouin net amplification in silicon-based nano-photonics

AIP Advances, 2019
Recent developments in on-chip forward Brillouin scattering open up potential applications such as RF photonic signal processing, on-chip Brillouin amplification, and on-chip Brillouin lasers.
Hyeongpin Kim, Heedeuk Shin
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Micro Saddle Coil with Switchable Sensitivity for Local High-Resolution Imaging of Luminal Tissue

Micromachines, 2016
This paper reports on a micro saddle coil for local high-resolution magnetic resonance imaging (MRI) fabricated by embedding a flexible coil pattern into a polydimethyilsiloxane (PDMS) tube.
Tetsuji Dohi, Kousuke Murashige
doaj   +1 more source