Results 71 to 80 of about 2,796,396 (258)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

High-Power Emission via Large-Area VCSELs With Single High-Order Mode Operation

open access: yesIEEE Photonics Journal
In this work we investigate patterned large-active area AlGaAs vertical-cavity surface-emitting lasers (VCSELs) targeting high-power single-transverse-mode emission.
Valerio Torrelli   +5 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

open access: yesFEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis   +2 more
wiley   +1 more source

Thermally induced mode loss evolution in the coiled ytterbium doped large mode area fiber.

open access: yesOptics Express, 2017
We propose a model to calculate the thermally induced mode loss evolution in the coiled ytterbium doped large mode area (LMA) fiber. The mode loss evolution in the coiled conventional step index LMA 20/400 fiber is investigated.
Ling-Chao Kong   +3 more
semanticscholar   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Anti-Resonant Fiber with Large Mode Area and Ultra-High HOMER for Near-Infrared High-Power Laser

open access: yesPhotonics
A novel anti-resonant hollow-core fiber (AR-HCF) is proposed. The fiber uses cross-nested circular cladding tubes including single-nested and non-nested tubes in the near-infrared spectral region of 1.3–1.7 μm.
Shuyi Wang   +9 more
doaj   +1 more source

Large-mode-area fibers operating near single-mode regime.

open access: yesOptics Express, 2016
Lower NA in large-mode-area fibers enables better single-mode operation and larger core diameters. Fiber NA has traditionally been limited to 0.06, mostly due to the control tolerance in the fabrication process.
Fan-Ting Kong   +6 more
semanticscholar   +1 more source

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