Results 101 to 110 of about 618,573 (283)

Anti-Resonant Fiber with Large Mode Area and Ultra-High HOMER for Near-Infrared High-Power Laser

Photonics
A novel anti-resonant hollow-core fiber (AR-HCF) is proposed. The fiber uses cross-nested circular cladding tubes including single-nested and non-nested tubes in the near-infrared spectral region of 1.3–1.7 μm.
Shuyi Wang, Guangrong Sun, Meng Wang, Linyong Yang, Yangweinan Cai, Jing Shi, Peicong Liu, Zhiyue Zhou, Zilun Chen, Zefeng Wang   +9 more
doaj   +1 more source

High power femtosecond chirped pulse amplification in large mode area photonic bandgap Bragg fibers

, 2011
International audienceWe report on high power amplification of femtosecond pulses in 40-μm core diameter Yb-doped photonic bandgap Bragg fibers. The robustness to bending and transverse spatial behavior of these fibers is analyzed through simulations ...
Daniault, Louis, Druon, Frédéric, Février, Sébastien, Gaponov, Dmitry, Georges, Patrick, Hanna, Marc, Likhachev, M.E., Roy, Philippe, Salganskii, M.Y., Yashkov, M.V.   +9 more
core   +4 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Millimeter-long Fiber Fabry-Perot cavities

, 2016
We demonstrate fiber Fabry-Perot (FFP) cavities with concave mirrors that can be operated at cavity lengths as large as 1.5mm without significant deterioration of the finesse.
Garcia, Sebastien, Kohlhaas, Ralf, Long, Romain, Ott, Konstantin, Reichel, Jakob, Rosenbusch, Peter, Schüppert, Klemens   +6 more
core   +3 more sources

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Design of Mixed-mode Readout Electronics for Large-area SiPM Arrays

Yuanzineng kexue jishu
Accurate localization of radioactive material is essential for finding “orphan sources”, decontaminating and decommissioning nuclear facilities, and optimizing radiation protection.
HE Lei1, 2, ZHAO Xiuliang1, , HUANG Yuefeng2, HOU Huiliang2, 3, AN Kunhao2, 3
doaj   +1 more source

Mode-adaptive control of a kilowatt-level large-mode-area fiber laser based on 5×1 photonic lantern

High Power Laser Science and Engineering
This study presents high-power mode-selective operation in a large-mode-area (LMA) fiber laser. A spatial mode-adaptive control system incorporating a 5×1 photonic lantern was employed to facilitate mode conversion between the LP01 and LP11 modes.
Wenguang Liu, Yanyang Hu, Hanwei Zhang, Lianchuang Ding, Pengfei Liu, Baozhu Yan, Jiangbin Zhang, Qiong Zhou, Zongfu Jiang   +8 more
doaj   +1 more source

Large Mode Area Photonic Crystal Fibers

, 2004
The photonic crystal fiber (PCF) is a novel single-material optical waveguide realized by an arrangement of air-holes running along the full length of the fiber. Since the proposal of the PCF in 1996, the technology has developed into being a well-established area of research and commercialisation.
Nielsen, Martin Dybendal, Bjarklev, Anders Overgaard, Simonsen, Harald R.   +2 more
openaire   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source