Results 111 to 120 of about 631,512 (303)

Large on-chip Brillouin net amplification in silicon-based nano-photonics

AIP Advances, 2019
Recent developments in on-chip forward Brillouin scattering open up potential applications such as RF photonic signal processing, on-chip Brillouin amplification, and on-chip Brillouin lasers.
Hyeongpin Kim, Heedeuk Shin
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Stress-Induced Polarization-Maintaining Large-Mode-Area Photonic Crystal Fibers With Deviation of the Single-Mode Transmission Band and Delocalization of Higher-Order Modes

IEEE Photonics Journal
The nonlinear effects and laser-induced optical and thermal damage in optical fibers, together with the limitations of beam quality and mode-field area, restrict the power scaling-up of single-mode output for developing high-power fiber lasers in the ...
Yuan Ma, Rui Wan, Huanhuan Yang, Yanfu Li, Chao Chen, Pengfei Wang   +5 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Hollow core large mode area fibre employing a subwavelength grating reflector

Hollow core large mode area fibres are ideal candidates to guide light at high powers while avoiding non-linear effects and, as such, they are generating much scientific interest.
Vukovic, N.A., Zervas, M.N.
core  

New solid fully-aperiodic large pitch fibers with non-filamented core for high-power singlemode emission

, 2015
International audienceWe report on the first high power laser emission of a solid triple-clad fully-aperiodic large mode area fiber with non-filamented core based on Repusil process.
Benoit, Aurélien, Darwich, Dia, Dauliat, Romain, Grimm, Stephan, Jamier, Raphaël, Kobelke, Jens, Roy, Philippe, Salin, François, Schuster, Kay   +8 more
core   +3 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Adjoint Algorithm Design of Selective Mode Reflecting Metastructure for BAL Applications

Nanomaterials
Broad-area lasers (BALs) have found applications in a variety of crucial fields on account of their high output power and high energy transfer efficiency.
Zean Li, Xunyu Zhang, Cheng Qiu, Yingshuai Xu, Zhipeng Zhou, Ziyuan Wei, Yiman Qiao, Yongyi Chen, Yubing Wang, Lei Liang, Yuxin Lei, Yue Song, Peng Jia, Yugang Zeng, Li Qin, Yongqiang Ning, Lijun Wang   +16 more
doaj   +1 more source