Results 111 to 120 of about 618,573 (283)
Large on-chip Brillouin net amplification in silicon-based nano-photonics
AIP Advances, 2019 Recent developments in on-chip forward Brillouin scattering open up potential applications such as RF photonic signal processing, on-chip Brillouin amplification, and on-chip Brillouin lasers.
Hyeongpin Kim, Heedeuk Shin
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
IEEE Photonics JournalThe nonlinear effects and laser-induced optical and thermal damage in optical fibers, together with the limitations of beam quality and mode-field area, restrict the power scaling-up of single-mode output for developing high-power fiber lasers in the ...
Yuan Ma +5 more
doaj +1 more source
Hollow core large mode area fibre employing a subwavelength grating reflector
Hollow core large mode area fibres are ideal candidates to guide light at high powers while avoiding non-linear effects and, as such, they are generating much scientific interest.
Vukovic, N.A., Zervas, M.N.
core
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
, 2015 International audienceWe report on the first high power laser emission of a solid triple-clad fully-aperiodic large mode area fiber with non-filamented core based on Repusil process.
Benoit, Aurélien +8 more
core +3 more sources
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Adjoint Algorithm Design of Selective Mode Reflecting Metastructure for BAL Applications
NanomaterialsBroad-area lasers (BALs) have found applications in a variety of crucial fields on account of their high output power and high energy transfer efficiency.
Zean Li +16 more
doaj +1 more source