Results 81 to 90 of about 14,107,293 (207)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Background, Aims, and Theories of the Comparative Large-Scale Studies in Education

, 2022
A large body of knowledge and competence has accumulated since the first international large-scale assessment (ILSA) was implemented in the 1960s. Moreover, ILSA inspired numerous valuable debates about education, policy, assessment, and measurement over
Gustafsson, Jan-Eric,, Stancel-Piatak, Agnes, Nilsen, Trude   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Artificial Intelligence in Science and Mathematics Assessment for Students with Disabilities: Opportunities and Challenges

Education Sciences
Emerging developments in artificial intelligence present significant opportunities to enhance equity and access to science and mathematics assessment content for students with disabilities. Artificial intelligence (AI) technologies may have the potential
Amy K. Clark, Ashley Hirt, David Whitcomb, W. Jake Thompson, Marjorie Wine, Meagan Karvonen   +5 more
doaj   +1 more source

Toward large scale assessment of information and communication technology literacy: Implementation considerations for the ETS ICT literacy instrument

, 2007
Purpose\ud \ud The purpose of this paper is to provide guidance to those contemplating or preparing to administer a large scale information literacy assessment such as the ETS ICT assessment instrument. The case studies and literature review provide real
Harlan, Sallie, Schader, Barbara, Dabbour, Katherine S., Somerville, Mary M., Lampert, Lynn D.   +4 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Response rates in low-stakes testing: insights from the Italian experience in large-scale assessments

Frontiers in Education
Achieving high response rates in international large-scale assessments (ILSAs) is crucial for ensuring data validity and cross-national comparability. The first part of this article reviewed the literature on response rates in low-stakes assessments and ...
Laura Palmerio, Elisa Caponera
doaj   +1 more source

Flood risk assessment through large-scale modeling under uncertainty [PDF]

Natural Hazards and Earth System Sciences
The complexity of flood risk models is intrinsically linked to a variety of sources of uncertainty (hydrology, hydraulics, exposed assets, vulnerability, coping capacity, etc.) that affect the accuracy and reliability of the analyses.
L. Pavesi, E. Volpi, A. Fiori
doaj   +1 more source