Impact of Climate Change and Heat Stress on Milk Production in Korean Holstein Cows: A Large-Scale Data Analysis. [PDF]
Animals (Basel), 2023 Jeon E, Jang S, Yeo JM, Kim DW, Cho K.
europepmc +1 more source
Correspondence Analysis Applied to Large Scale Evo-Devo Data
2019 42nd International Convention on Information and Communication Technology, Electronics and Microelectronics (MIPRO), 2019 Correspondence analysis (CA) is an exploratory method used for visualizing and understanding high dimensional data. It is mostly applied to contingency tables. Although the method has been used in various fields for decades, including bioinformatics, to our knowledge it has not yet been applied tothe evolutionary analysis ofgene expressiondata ...
Široki, Tin +5 more
openaire +2 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Large-Scale Data Analysis for Glucose Variability Outcomes with Open-Source Automated Insulin Delivery Systems. [PDF]
Nutrients, 2022 Shahid A, Lewis DM.
europepmc +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Latent network-based representations for large-scale gene expression data analysis
BMC Bioinformatics, 2019 Background With the recent advancements in high-throughput experimental procedures, biologists are gathering huge quantities of data. A main priority in bioinformatics and computational biology is to provide system level analytical tools capable of ...
Wajdi Dhifli +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Passenger Travel Regularity Analysis Based on a Large Scale Smart Card Data
Journal of Advanced Transportation, 2018 Analysis of passenger travel habits is always an important item in traffic field. However, passenger travel patterns can only be watched through a period time, and a lot of people travel by public transportation in big cities like Beijing daily, which ...
Qi Ouyang +4 more
doaj +1 more source
Large-scale data analysis for robotic yeast one-hybrid platforms and multi-disciplinary studies using GateMultiplex. [PDF]
BMC Biol, 2021 Tsai NC +13 more
europepmc +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source