Results 61 to 70 of about 431,408 (282)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Galaxy Spin Transition Driven by the Misalignments between the Protogalaxy Inertia and Initial Tidal Tensors

The Astrophysical Journal
A numerical detection of the τ -driven transition of galaxy spins is presented, where τ is the degree of misalignment between the initial tidal field and protogalaxy inertia tensors.
Jun-Sung Moon, Jounghun Lee
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

AI-powered Reconstruction of Dark Matter Velocity Fields from Redshift-space Halo Distribution

The Astrophysical Journal
We propose a UNet-based deep learning model to reconstruct the real-space dark matter (DM) velocity field from the redshift-space distribution of sparse DM halos.
Xu Xiao, Jiacheng Ding, Xiaolin Luo, Sun Ke Lan, Liang Xiao, Shuai Liu, Xin Wang, Le Zhang, Xiao-Dong Li   +8 more
doaj   +1 more source

Cosmological Information in the Marked Power Spectrum of the Galaxy Field

The Astrophysical Journal, 2023
Marked power spectra are two-point statistics of a marked field obtained by weighting each location with a function that depends on the local density around that point. We consider marked power spectra of the galaxy field in redshift space that up-weight
Elena Massara, Francisco Villaescusa-Navarro, ChangHoon Hahn, Muntazir M. Abidi, Michael Eickenberg, Shirley Ho, Pablo Lemos, Azadeh Moradinezhad Dizgah, Bruno Régaldo-Saint Blancard   +8 more
doaj   +1 more source

Turbulence and Magnetic Fields in the Large Scale Structure of the Universe

, 2008
The nature and origin of turbulence and magnetic fields in the intergalactic space are important problems that are yet to be understood. We propose a scenario in which turbulent flow motions are induced via the cascade of the vorticity generated at ...
Cho, Jungyeon, Das, Santabrata, Kang, Hyesung, Ryu, Dongsu   +3 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Exploring the Signature of Assembly Bias and Modified Gravity Using Small-scale Clusterings of Galaxies

The Astrophysical Journal
We apply a halo velocity bias model, γ _f , within the Aemulus simulation suite for General Relativity to investigate its efficacy in identifying the signature of assembly bias and Modified Gravity (MG).
Yirong Wang, Zhongxu Zhai, Xiaohu Yang, Jeremy L. Tinker   +3 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source