Results 81 to 90 of about 430,581 (306)
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
The Astrophysical JournalA numerical detection of the τ -driven transition of galaxy spins is presented, where τ is the degree of misalignment between the initial tidal field and protogalaxy inertia tensors.
Jun-Sung Moon, Jounghun Lee
doaj +1 more source
Data-driven Cosmology from Three-dimensional Light Cones
The Astrophysical Journal, 2023 We present a data-driven technique to analyze multifrequency images from upcoming cosmological surveys mapping large sky area. Using full information from the data at the two-point level, our method can simultaneously constrain the large-scale structure (
Yun-Ting Cheng +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
AI-powered Reconstruction of Dark Matter Velocity Fields from Redshift-space Halo Distribution
The Astrophysical JournalWe propose a UNet-based deep learning model to reconstruct the real-space dark matter (DM) velocity field from the redshift-space distribution of sparse DM halos.
Xu Xiao +8 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
Stabilization of Large Scale Structure by Adhesive Gravitational Clustering [PDF]
, 1999 The interplay between gravitational and dispersive forces in a multi-streamed medium leads to an effect which is exposed in the present note as the genuine driving force of stabilization of large-scale structure. The conception of `adhesive gravitational
Buchert, Thomas
core +3 more sources
Turbulence and Magnetic Fields in the Large Scale Structure of the Universe
, 2008 The nature and origin of turbulence and magnetic fields in the intergalactic space are important problems that are yet to be understood. We propose a scenario in which turbulent flow motions are induced via the cascade of the vorticity generated at ...
Cho, Jungyeon +3 more
core +1 more source