Results 101 to 110 of about 3,127,622 (352)

No very large scale structure in an open universe

open access: yesPhysical Review D, 1995
25 pages of TeX. PostScript including figures available at ftp://ftp-astro-theory.fnal.gov/pub/Publications/Pub-94-386-A/
Albert Stebbins, Robert R. Caldwell
openaire   +4 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

On the structure of universal differentiability sets [PDF]

open access: yesarXiv, 2016
We prove that universal differentiability sets in Euclidean spaces possess distinctive structural properties. Namely, we show that any universal differentiability set contains a `kernel' in which the points of differentiability of each Lipschitz function are dense.
arxiv  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Universal enveloping TROs and structure of W*-TROs [PDF]

open access: yesarXiv, 2016
Calculation of the universal enveloping TROs of continuous JBW$*-triples, and application of the techniques used to supplement the structural results of Ruan for W*-TROs.
arxiv  

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

open access: yesMolecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

On hierarchies of universal predicates [PDF]

open access: yesarXiv, 2007
We investigate a hierarchy of arithmetical structures obtained by a transfinite addition of a canonic universal predicate, where the canonic universal predicate for M is defined as a minimum universal predicate for M in terms of definability. We determine the upper bound of the hierarchy and give a characterisation for the sets definable in the ...
arxiv  

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

open access: yesMolecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova   +18 more
wiley   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

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