Results 111 to 120 of about 91,637 (344)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Gravitationally Induced Quantum Superposition Reduction With Large Extra Dimensions

, 2006
A gravity-driven mechanism (``objective reduction\u27\u27) proposed to explain quantum state reduction is analyzed in light of the possible existence of large extra dimensions in the ADD scenario.
J. R. Mureika, Mureika, Jonas R.
core   +1 more source

Brane-World Gravity [PDF]

, 2010
The observable universe could be a 1+3-surface (the “brane”) embedded in a 1+3+d-dimensional spacetime (the “bulk”), with Standard Model particles and fields trapped on the brane while gravity is free to access the bulk.
Roy Maartens, Kazuya Koyama, Maartens, Roy, Koyama, Kazuya   +3 more
core   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Constraining compressed versions of MUED and MSSM using soft tracks at the LHC

Journal of High Energy Physics, 2017
A compressed spectrum is an anticipated hideout for many beyond standard model scenarios. Such a spectrum naturally arises in the minimal universal extra dimension framework and also in supersymmetric scenarios.
Sabyasachi Chakraborty, Saurabh Niyogi, K. Sridhar   +2 more
doaj   +1 more source

Black holes at accelerators

, 2010
In theories with large extra dimensions and TeV-scale gravity, black holes are copiously produced in particle collisions at energies well above the Planck scale.

core  

Neutrino oscillations and large extra dimensions

, 2000
Assuming that right-handed neutrinos exist and propagate in some large extra dimensions, we attempt to give a comprehensive description of the phenomenology of neutrino oscillations.
Barbieri R, STRUMIA, ALESSANDRO, Alessandro Strumia, Creminelli P, Riccardo Barbieri, Paolo Creminelli   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Gauge Mediated Supersymmetry Breaking in Five Dimensions

, 2011
PhDIn this thesis we focus on the construction of models in which a supersymmetry breaking hidden sector is located on one fixed point of an extra dimensional interval and the effects are gauge mediated across this interval to the other fixed point ...
McGarrie, Moritz
core  

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source