Results 121 to 130 of about 91,460 (300)

Cosmological constraints on theories with large extra dimensions [PDF]

, 1999
In theories with large extra dimensions, constraints from cosmology lead to non-trivial lower bounds on the gravitational scale M, corresponding to upper bounds on the radii of the compact extra dimensions.
Smith, David, Hall, Lawrence J.
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Axion in large extra dimension

, 1999
We examine the axion model in the large extra dimensions scenario with TeV scale gravity. To obtain an intermediate-scale decay constant of the axion, the axion is assumed to live in a sub-spacetime (brane) of the whole bulk. In this model there appear Kaluza-Klein modes of the axion which have stronger interaction than those of the graviton. The axion
Chang, Sanghyeon, Tazawa, Shiro, Yamaguchi, Masahiro   +2 more
openaire   +2 more sources

Direct collider signatures of large extra dimensions [PDF]

, 1999
The realization of low (TeV) scale strings usually requires the existence of large (TeV) extra dimensions where gauge bosons live. The direct production of Kaluza-Klein excitations of the photon and Z-boson at present and future colliders is studied in ...
M. Quirós, Benakli, K., I. Antoniadis, K. Benakliand, Antoniadis, Ignatios, Quiros, M.   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Scalar-gravitational quasinormal modes and echoes in a five dimensional thick brane

Journal of High Energy Physics
The graviscalar perturbations of thick braneworld models provide critical insights into their matter-geometry relationship, distinct from tensor modes.
Weike Deng, Sheng Long, Qin Tan, Zu-Cheng Chen, Jiliang Jing   +4 more
doaj   +1 more source

Extra Spacetime Dimensions and Unification [PDF]

, 1998
We study the effects of extra spacetime dimensions at intermediate mass scales, as expected in string theories with large-radius compactifications, and focus on the gauge and Yukawa couplings within the Minimal Supersymmetric Standard Model. We find that
Gherghetta, Tony, Dudas, Emilian, Keith R. Dienes, Tony Gherghetta, Dienes, Keith R., Emilian Dudas   +5 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source