Results 81 to 90 of about 1,290,183 (324)

Quasinormal ringing of de Sitter braneworlds

Journal of High Energy Physics
Compared with the Poincaré braneworld, the de Sitter (dS) braneworld aligns more closely with the present universe characterized by a small but finite cosmological constant.
Hai-Long Jia, Wen-Di Guo, Yu-Xiao Liu, Qin Tan   +3 more
doaj   +1 more source

Tensor perturbations and thick branes in higher-dimensional f(R) gravity

Journal of High Energy Physics, 2020
We study brane worlds in an anisotropic higher-dimensional spacetime within the context of f(R) gravity. Firstly, we demonstrate that this spacetime with a concrete metric ansatz is stable against linear tensor perturbations under certain conditions ...
Zheng-Quan Cui, Zi-Chao Lin, Jun-Jie Wan, Yu-Xiao Liu, Li Zhao   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Collapse of Large Extra Dimensions [PDF]

, 2001
In models of spacetime that are the product of a four-dimensional spacetime with an ``extra'' dimension, there is the possibility that the extra dimension will collapse to zero size, forming a singularity.
C.D. Hoyle, D. Christodoulou, G.T. Horowitz, I. Antoniadis, J.D. Bekenstein, J.D. Bekenstein, J.M. Overduin, James Geddes, L. Amendola, L. Randall, L. Randall, M.W. Choptuik, N. Arkani-Hamed, N. Arkani-Hamed, O. Klein, O. Klein, R. Gregory, Th. Kaluza, U. Günther, V.A. Rubakov, W.D. Goldberger   +20 more
core   +2 more sources

Localization of scalar field on the brane-world by coupling with gravity

Journal of High Energy Physics
In this paper, we consider a coupling mechanism between the kinetic term and the gravity, in which a coupling function F (R) is introduced into the kinetic term of the five-dimensional scalar field. Based on this scenario, we investigate the localization
Heng Guo, Yong-Tao Lu, Cai-Ling Wang, Yue Sun   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Neutrino anomalies and large extra dimensions [PDF]

, 2001
Theories with large extra dimensions can generate small neutrino masses when the standard model neutrinos are coupled to singlet fermions propagating in higher dimensions.
A. Das, A. Ioannisian, A. Ioannission, A. Lukas, A. Lukas, A. S. Joshipura, A. Y. Smirnov, A. Zee, A. Zee, Amol S. Dighe, Anjan S. Joshipura, C. Athanassopoulos, C. Jarlskog, D. Chang, D. O. Caldwell, D. O. Caldwell, D. O. Caldwell, E. J. Chun, E. Ma, E. Ma, G. Dvali, I. Antoniadis, J. Cosme, J. Peltoniemi, K. Dienes, K. Eitel, K. Eitel, K. R. Dienes, M. Apollonio, M. C. Gonzalez-Garcia, N. Arkani-Hamed, N. Arkani-Hamed, O. Peres, P. H. Frampton, Q. R. Ahmad, R. Barbieri, R. Foot, R. N. Mohapatra, R. N. Mohapatra, R. N. Mohapatra, S. Fukuda, S. Fukuda, S. M. Bilenky, V. Barger, W. Grimus, W. Grimus, Z. Berezhiani   +46 more
core   +2 more sources

Resummed inclusive cross-section in ADD model at N3LL

Journal of High Energy Physics, 2020
We present three loop soft-plus-virtual (SV) corrections to the spin-2 production at the Large Hadron Collider (LHC). For this calculation, we make use of the recently computed quark and gluon three loop form factors for the spin-2 production, the ...
Goutam Das, M. C. Kumar, Kajal Samanta
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Gravitational echoes from braneworlds

Journal of High Energy Physics
Gravitational echoes can be used to probe the structure of spacetime. In this paper, we investigate the gravitational echoes in different braneworld models in five-dimensional spacetime. We derive the gravitational perturbation equations of these models,
Chun-Chun Zhu, Jing Chen, Wen-Di Guo, Yu-Xiao Liu   +3 more
doaj   +1 more source