Results 41 to 50 of about 3,008,888 (261)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Review of key technologies in knowledge graphs powered by code large language models

大数据
Traditional knowledge graph technologies still face significant challenges in converting human knowledge, expressed in natural language, into a formal language-based knowledge graph and utilizing it effectively.
LI Zixuan, BAI Long, REN Weicheng, SU Miao, LIU Wenxuan, CHEN Lei³, JIN Xiaolong   +6 more
doaj   +2 more sources

Knowledge-guided large language model for material science

Review of Materials Research
With ChatGPT starting a storm of transformative applications worldwide, the advent of large language models (LLMs) has revolutionized the paradigm of scientific research, shifting from data-driven methods to AI-driven science.
Guanjie Wang, Jingjing Hu, Jian Zhou, Sen Liu, Qingjiang Li, Zhimei Sun   +5 more
doaj   +1 more source

The language of certain conflicts of a nondeterministic process [PDF]

, 2010
The language of certain conflicts is the most general set of behaviours of a nondeterministic process, which certainly lead to a livelock or deadlock when accepted by another process running in parallel.
Malik, Robi
core   +1 more source

Speeding up Context-based Sentence Representation Learning with Non-autoregressive Convolutional Decoding

, 2018
Context plays an important role in human language understanding, thus it may also be useful for machines learning vector representations of language.
de Sa, Virginia R., Fang, Chen, Jin, Hailin, Tang, Shuai, Wang, Zhaowen   +4 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

A large language model for electronic health records

npj Digital Medicine, 2022
There is an increasing interest in developing artificial intelligence (AI) systems to process and interpret electronic health records (EHRs). Natural language processing (NLP) powered by pretrained language models is the key technology for medical AI ...
Xi Yang, Aokun Chen, Nima PourNejatian, Hoo Chang Shin, Kaleb E. Smith, Christopher Parisien, Colin Compas, Cheryl Martin, Anthony B. Costa, Mona G. Flores, Ying Zhang, Tanja Magoc, Christopher A. Harle, Gloria Lipori, Duane A. Mitchell, William R. Hogan, Elizabeth A. Shenkman, Jiang Bian, Yonghui Wu   +18 more
doaj   +1 more source

Unsupervised Transfer Learning for Spoken Language Understanding in Intelligent Agents

, 2018
User interaction with voice-powered agents generates large amounts of unlabeled utterances. In this paper, we explore techniques to efficiently transfer the knowledge from these unlabeled utterances to improve model performance on Spoken Language ...
Goyal, Anuj, Metallinou, Angeliki, Siddhant, Aditya   +2 more
core   +1 more source

Talking about Large Language Models

Communications of the ACM
Interacting with a contemporary LLM-based conversational agent can create an illusion of being in the presence of a thinking creature. Yet, in their very nature, such systems are fundamentally not like us.
openaire   +4 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source