Results 51 to 60 of about 515,234 (309)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Large Language Models Are Biased Because They Are Large Language Models

Computational Linguistics
Abstract This position paper’s primary goal is to provoke thoughtful discussion about the relationship between bias and fundamental properties of large language models (LLMs). I do this by seeking to convince the reader that harmful biases are an inevitable consequence arising from the design of any large language model as LLMs are ...
openaire   +2 more sources

Unpacking Large Language Models: Grundlagen, Perspektiven und Herausforderungen

Obwohl es statistische Sprachmodelle bereits seit den 1980ern gibt, konnte erst ChatGPT, welches im Winter 2022 veröffentlicht wurde, das Interesse der breiten Gesellschaft für diese Technologie wecken.
Kraft, Angelie
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Understanding Open Source Large Language Models: An Exploratory Study

132140Prompted by the increasing dominance of proprietary Large Language Models (LLMs), such as OpenAI’s GPT-4 and Google’s Gemini, concerns about data privacy, accessibility and bias have led to a growing advocacy for OSLLMs.
Mou, Yongli, Sowe, Sulayman K., Cheng, Du, Kong, Lingxiao, Neumann, Alexander Tobias, Decker, Stefan   +5 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

A Comprehensive Survey of Large Language Models and Multimodal Large Language Models in Medicine

Information Fusion
Since the release of ChatGPT and GPT-4, large language models (LLMs) and multimodal large language models (MLLMs) have attracted widespread attention for their exceptional capabilities in understanding, reasoning, and generation, introducing transformative paradigms for integrating artificial intelligence into medicine.
Hanguang Xiao, Feizhong Zhou, Xingyue Liu, Tianqi Liu, Zhipeng Li, Xin Liu, Xiaoxuan Huang   +6 more
openaire   +2 more sources

Large Language Models – Von Bard bis BERT und ChatGPT

Damals, April 2023 auf der Jahrestagung in Berlin, haben wir gefragt: Können wir uns nicht auch mal bei SAP in Walldorf treffen? Und über welches Thema wollen wir sprechen?
Schmitz, Denise, Lisker, Mareike, Zschiesche, Claire   +2 more
core   +1 more source

Personality Emulation Utilizing Large Language Models

Applied Sciences
Fake identities have proven to be an effective methodology for conducting privacy and cybersecurity research; however, existing models are limited in their ability to interact with and respond to received communications.
Jack Kolenbrander, Alan J. Michaels
doaj   +1 more source

Augmenting interpretable models with large language models during training

Nature Communications, 2023
Recent large language models (LLMs), such as ChatGPT, have demonstrated remarkable prediction performance for a growing array of tasks. However, their proliferation into high-stakes domains and compute-limited settings has created a burgeoning need for ...
Chandan Singh, Armin Askari, Rich Caruana, Jianfeng Gao   +3 more
doaj   +1 more source