Results 51 to 60 of about 16,605,417 (300)
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Understanding Open Source Large Language Models: An Exploratory Study
132140Prompted by the increasing dominance of proprietary Large Language Models (LLMs), such as OpenAI’s GPT-4 and Google’s Gemini, concerns about data privacy, accessibility and bias have led to a growing advocacy for OSLLMs.
Mou, Yongli +5 more
core +1 more source
Steganography with Large Language Models
Proceedings of the International Florida Artificial Intelligence Research Society ConferenceLarge language model (LLM) steganography generates fluent cover text that encodes a secret message, with the secret key often given as a natural language prompt or seed.
Alexander V Mantzaris +4 more
doaj +2 more sources
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Large Language Models – Von Bard bis BERT und ChatGPT
Damals, April 2023 auf der Jahrestagung in Berlin, haben wir gefragt: Können wir uns nicht auch mal bei SAP in Walldorf treffen? Und über welches Thema wollen wir sprechen?
Schmitz, Denise +2 more
core +1 more source
Openai API, LLM (Large Language Models) [PDF]
La API de OpenAI es una interfaz de programación que proporciona acceso a modelos avanzados de inteligencia artificial (IA) desarrollados por OpenAI, específicamente Modelos de Lenguaje Grande (LLM), como GPT-3 y GPT-4.
Santa Quintero, Ricardo Andres +2 more
core +4 more sources
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Large Language Models as Kuwaiti Annotators
Big Data and Cognitive ComputingStance detection for low-resource languages, such as the Kuwaiti dialect, poses a significant challenge in natural language processing (NLP) due to the scarcity of annotated datasets and specialized tools.
Hana Alostad
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source