Results 81 to 90 of about 1,632,251 (310)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
A torsion test for the study of the large deformation recovery of shape memory polymers [PDF]
, 2011 A torsion device was designed and built for testing the shape fixity and shape recovery of shape memory polymers at large deformation. A simple thermal chamber was used to regulate the thermal environment during testing and a CCD camera was used for ...
GILORMINI, Pierre +11 more
core +1 more source
Analysis of a Thermo-Viscoelastic Model in Large Strain [PDF]
Civil-Comp Proceedings, 2009 no ...
Méo, Stéphane +2 more
openaire +3 more sources
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Metalurgija, 2019 In this paper are reported the results of an extensive and innovative mechanical characterization carried out on three large diameter line pipes for gas transportation useful to calibrate a new plasticity finite element numerical simulation (FEM) model ...
F. Iob, T. Coppola, A. Di Schino
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The Lodge Rubberlike Liquid Behavior for Cheese in Large Amplitude Oscillatory Shear
Applied Rheology, 2001 The viscoelasticity of reduced-fat Cheddar and Mozzarella cheeses was characterized in small (parallel disk rheometer, go = 0.01) and large (sliding plate rheometer, 0.2< go
Wang Y.-C. +2 more
doaj +1 more source
Novel B19′ strain glass with large recoverable strain
Physical Review Materials, 2017 We report a strain glass state (B19\ensuremath{'} strain glass) in a Ni-rich TiNi shape memory alloy produced by cold rolling. As compared to previously reported strain glasses, this strain glass state has outstanding properties including quasilinear superelasticity with a large recoverable strain (\ensuremath{\sim}4%), and slim hysteresis and high ...
Qianglong Liang +7 more
openaire +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source