Disabilities and Handicaps of Patients with Laron Syndrome [PDF]
ChildrenBackground: Laron Syndrome (LS) is a rare hereditary form of dwarfism occurring, with few exceptions, in Jewish, Muslim, and Asian populations or their descendants spread over all continents. It is caused by deletions or mutations in the GH-Receptor gene,
Zvi Laron
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Journal of the ASEAN Federation of Endocrine Societies, 2023 Primary growth hormone (GH) resistance or growth hormone insensitivity syndrome, also called Laron syndrome, is a hereditary disease caused by mutations in the GH receptor or in the post-receptor signaling pathway.
Niladri Das +7 more
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Laron Syndrome Research Paves the Way for New Insights in Oncological Investigation [PDF]
Cells, 2020 Laron syndrome (LS) is a rare genetic endocrinopathy that results from mutation of the growth hormone receptor (GH-R) gene and is typically associated with dwarfism and obesity.
Haim Werner +3 more
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Comparison Between Chronological and Bone Age at Menarche in Girls with Laron Syndrome [PDF]
ChildrenBackground: In the literature, the occurrence of menarche, the index of female sexual maturation, is related to chronological age (CA), but in conditions of abnormal growth it was proposed that determination of bone age (BA) was a better index of ...
Avivah Silbergeld, Zvi Laron
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Genome-Wide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways [PDF]
Cells, 2019 Laron syndrome (LS), or primary growth hormone resistance, is a prototypical congenital insulin-like growth factor 1 (IGF1) deficiency. The recent epidemiological finding that LS patients do not develop cancer is of major scientific and clinical ...
Haim Werner +9 more
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Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer [PDF]
Journal of Translational Medicine, 2018 Background Laron syndrome is an autosomal disease resulting from mutations in the growth hormone receptor (GHR) gene. The only therapeutic treatment for Laron syndrome is recombinant insulin-like growth factor I (IGF-I), which has been shown to have ...
Honghao Yu +12 more
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Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver [PDF]
Molecular Metabolism, 2018 Objective: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene.
Arne Hinrichs +18 more
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Insulin-like growth factors and aging: lessons from Laron syndrome [PDF]
Frontiers in Endocrinology, 2023 The growth hormone (GH)-insulin-like growth factor-1 (IGF1) signaling pathway emerged in recent years as a key determinant of aging and longevity.
Haim Werner, Zvi Laron
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Laron Syndrome (LS) – A Rare Case Report [PDF]
Journal of Clinical and Biomedical SciencesLaron syndrome or growth hormone insensitivity (GHI) is a rare genetic disease inherited in an autosomal recessive manner. A 6 ½ year-old-female child was bought to Paediatric OPD for short stature which was noticed by parents since 3 years of age ...
Deepthi S S N S P +3 more
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Role of the GH-IGF1 axis on the hypothalamus–pituitary–testicular axis function: lessons from Laron syndrome [PDF]
Endocrine Connections, 2021 Background: Animal studies suggest that insulin-like growth factor 1 (IGF1 ) may influence the function of the hypothalamus–pituitary–testicular axis, especially in childhood, but the evidence in humans is scanty.
Rossella Cannarella +4 more
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