Results 31 to 40 of about 3,629,719 (185)

Cancer in Ecuadorian subjects with Laron syndrome (ELS)

Endocrine-Related Cancer, 2023
Meta-analyses from 2018–2022 have shown that obesity increases the risk of various cancers such as acute myeloid lymphoma, chronic myeloid lymphoma, diffuse beta cell lymphoma, Hodgkin's lymphoma, leukemia, multiple myeloma, non-Hodgkin's lymphoma, bladder, breast, cholangiocarcinoma, colorectal, ovarian, esophageal, kidney, liver, prostate, thyroid ...
Jaime Guevara-Aguirre, Gabriela Peña, Gabriel Pazmiño, William Acosta, Jannette Saavedra, Daniela Lescano, Alexandra Guevara, Antonio W D Gavilanes   +7 more
openaire   +3 more sources

The globe and orbit in Laron syndrome. [PDF]

AJNR Am J Neuroradiol, 2011
Patients with LS have an inborn growth hormone resistance, resulting in failure to generate IGF-1. The purpose of this study was to evaluate the size of the eye and orbit in LS.We retrospectively reviewed the MR imaging of the brain in 9 patients with LS for the following parameters: axial diameter of the globe, interzygomatic distance, perpendicular ...
Kornreich L, Konen O, Lilos P, Laron Z.
europepmc   +4 more sources

Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity [PDF]

Molecular Metabolism
Background and aims: Fasting hypoglycemia has clinical implications for children with growth hormone (GH)-insensitivity syndrome. This study investigates the pathophysiology of juvenile hypoglycemia in a large animal model for GH receptor (GHR ...
Arne Hinrichs, Kalliopi Pafili, Gencer Sancar, Laeticia Laane, Silja Zettler, Malek Torgeman, Barbara Kessler, Judith Leonie Nono, Sonja Kunz, Birgit Rathkolb, Cristina Barosa, Cornelia Prehn, Alexander Cecil, Simone Renner, Elisabeth Kemter, Sabine Kahl, Julia Szendroedi, Martin Bidlingmaier, John Griffith Jones, Martin Hrabĕ de Angelis, Michael Roden, Eckhard Wolf   +21 more
doaj   +2 more sources

High growth hormone serum partially protects mice against Trypanosoma cruzi infection

FEBS Open Bio, 2023
Chagas disease (CD) is one of the most devasting parasitic diseases in the Americas, affecting 7–8 million people worldwide. In vitro and in vivo experiments have demonstrated that growth hormone (GH) serum levels decrease as CD progresses. Interestingly,
Patricia Mora‐Criollo, Reetobrata Basu, Yanrong Qian, Kevin Funk, Stephen Bell, Jonathan A. Young, Edward O. List, Jaime A. Costales, Jaime Guevara‐Aguirre, Mario J. Grijalva, John J. Kopchick   +10 more
doaj   +2 more sources

A CHILD WITH LARON SYNDROME ASSOCIATED WITH VASCULITIS. [PDF]

Acta Endocrinol (Buchar), 2016
Levels of insulin-like growth factor-I are characteristically low in Laron syndrome which is a factor that has important roles on vascular health and development. Congenital insulin-like growth factor-I deficiency was reported to be associated with some vascular disorders.
Unsal Sac R, Tasar MA, Tiras U, Savas Erdeve S, Dallar Bilge Y.   +4 more
europepmc   +4 more sources

Mexican case report of a never‐treated Laron syndrome patient evolving to metabolic syndrome, type 2 diabetes, and stroke [PDF]

Clinical Case Reports, 2017
Key Clinical Message Glucose and lipid profile together with blood pressure should always be considered for low sera‐IGF‐1 patients. Even when adulthood is reached, IGF‐1 therapy in these patients should be pursued as metabolic and protective cellular ...
Inma Castilla‐Cortazar, Giovana Femat‐Roldán, Joel Rodríguez‐Rivera, Gabriel A. Aguirre, Mariano García‐Magariño, Irene Martín‐Estal, Luis Espinosa, Carlos Díaz‐Olachea   +7 more
doaj   +2 more sources

GH-resistant (Laron) mice: gene therapy with a liver-specific GH receptor causes unbalanced upregulation of female-biased and growth-related genes [PDF]

Frontiers in Endocrinology
Growth hormone (GH) receptor (GHR) mutations give rise to GH-resistance (Laron syndrome). We previously treated GH-resistant Ghr-/- mice (Laron mice) with adeno-associated virus (AAV) delivering mouse (m)Ghr controlled by a constitutively active liver ...
Joshua K. Tay, Joshua K. Tay, Kian Chuan Sia, Siti Humairah Mohd Rodhi, Shu Uin Gan, Zhen Ying Fu, Maxim Pyatkov, John J. Kopchick, Michael J. Waters, David J. Waxman, Kok-Onn Lee   +10 more
doaj   +2 more sources

Lessons from the Genetics of Laron Syndrome

Trends in Endocrinology and Metabolism, 1998
In the decade since the cloning and sequencing of the growth hormone receptor (GHR) and the recognition that the circulating GH-binding protein (GHBP) is structurally identical to the extracellular domain of the GHR, 34 mutations have been described.
Arlan L. Rosenbloom, Jaime Guevara-Aguirre   +1 more
exaly   +4 more sources

Laron syndrome: a case report

International Journal of Contemporary Pediatrics, 2021
Laron syndrome (LS) is a rare, genetic disorder inherited in an autosomal recessive manner. The disease is caused by mutations of the growth hormone (GH) gene, leading to GH/insulin-like growth factor type 1 (IGF1) signalling pathway defect. A 13-month-old, male child, born of second-degree consanguineous marriage presented with short stature (57 cm ...
Ashok V. Puttappanavar, Thanuja Basavanagowda, Sushma Shree, Savitha Mysore RamaRaj, Prashanth .   +4 more
openaire   +3 more sources

Primary growth hormone insensitivity (Laron syndrome) and acquired hypothyroidism: a case report [PDF]

Journal of Medical Case Reports, 2011
Introduction Primary growth hormone resistance or growth hormone insensitivity syndrome, also known as Laron syndrome, is a hereditary disease caused by deletions or different types of mutations in the growth hormone receptor gene or by post-receptor ...
Corneli Ginevra, Aimaretti Gianluca, Curtò Lorenzo, Santarpia Libero, Cotta Oana R, Trimarchi Francesco, Cannavò Salvatore   +6 more
doaj   +2 more sources