Results 51 to 60 of about 3,629,719 (185)

Orthopedic Problems in Laron Syndrome

, 2010
Orthopedic congenital malformations were dislocation of the hip and Perthes’ disease. Half of the patients had lack of elbow extension. With advancing age patients had problems with walking, related to spinal pathology. Despite lifelong IGF-I deficiency, Laron syndrome patients did not have more fractures than in the general population.
Zvi Laron, Rivka Kauli
openaire   +2 more sources

Laron Syndrome

, 1999
Zvi Laron
openaire   +2 more sources

The Teeth in Patients with Laron Syndrome

, 2010
Laron syndrome patients have delayed tooth eruption, crowding, many caries and a tendency to break. Histological examination revealed defects in enamel formation.
Zvi Laron
openaire   +2 more sources

Corrigendum to “Transient juvenile hypoglycemia in GH insensitive Laron syndrome pigs is associated with insulin hypersensitivity” [Mol Metabol (2025) 102273] [PDF]

Molecular Metabolism
Arne Hinrichs, Kalliopi Pafili, Gencer Sancar, Laeticia Laane, Silja Zettler, Malek Torgeman, Barbara Kessler, Judith Leonie Nono, Sonja Kunz, Birgit Rathkolb, Cristina Barosa, Cornelia Prehn, Alexander Cecil, Simone Renner, Elisabeth Kemter, Sabine Kahl, Julia Szendroedi, Martin Bidlingmaier, John Griffith Jones, Martin Hrabĕ de Angelis, Michael Roden, Eckhard Wolf   +21 more
doaj   +2 more sources

Laron syndrome in South Indian children – A descriptive study

Journal of Pediatric Endocrinology and Diabetes, 2023
The objectives of this study were to describe the clinical and biochemical features of five children with Laron syndrome (LS) from South India. This is a prospective descriptive case series of five children with clinical and biochemical features of ...
S. Rajalakshmi, Sabharritha Gunasekaran, H. Prasad, K. Gowrishankar, K. Narayanasamy, N. Krishnamoorthy   +5 more
semanticscholar   +1 more source

Elevated IGF‐1 concentrations in children with low grade glioma: A descriptive analysis in a retrospective national cohort

Journal of Neuroendocrinology, Volume 35, Issue 8, August 2023., 2023
Elevated IGF‐1 concentration (> +2 SDS) was found in 18.4% of childhood low grade glioma and seems to be related to hypothalamic dysfunction (BMI and posterior pituitary disorder) worsening over time. Abstract Children with low grade glioma (LGG) may present with, or develop, elevated concentrations of insulin‐like growth factor 1 (IGF‐1).
Jiska van Schaik, Ichelle M. A. A. van Roessel, Iris D. Bos, Hedi L. Claashen‐van der Grinten, Sarah C. Clement, Laura van Iersel, Boudewijn Bakker, Lisethe Meijer, Leontien Kremer, A. Y. Netteke Schouten‐van Meeteren, Hanneke M. van Santen   +10 more
wiley   +1 more source

Síndrome de Laron: Reporte de caso [PDF]

, 2023
Introducción e importancia: El síndrome de Laron es una condición genética rara, que se presenta con muy poca frecuencia. Esta enfermedad es tratada con un único medicamento denominado mecasermina para mejorar la calidad de vida del paciente, sin embargo,
Vergara Caraguay, Sarahi Alejandra
core   +1 more source

Patients with Laron syndrome are protected from development of cancer even if treated with IGF-I [PDF]

, 2013
In accordance with the link between increased GH and IGF-I secretion and cancer, we found that homozygous patients with Laron syndrome (severe GH insensitivity) and low to undetectable serum IGF-I are protected from developing cancer even if treated with
Rivka, Kauli, Zvi, Laron, Steuerman, Rachel, Orit, Shevah   +3 more
core   +1 more source

Conditional gene regulation models demonstrate a pro‐proliferative role for growth hormone receptor in prostate cancer

The Prostate, Volume 83, Issue 5, Page 416-429, April 2023., 2023
Abstract Background Humans with inactivating mutations in growth hormone receptor (GHR) have lower rates of cancer, including prostate cancer. Similarly, mice with inactivating Ghr mutations are protected from prostatic intraepithelial neoplasia in the C3(1)/TAg prostate cancer model. However, gaps in clinical relevance in those models persist.
Christopher J. Unterberger, Sean J. McIlwain, Philippos K. Tsourkas, Vilena I. Maklakova, Jordyn L. Prince, Abigail Onesti, Rong Hu, John J. Kopchick, Steven M. Swanson, Paul C. Marker   +9 more
wiley   +1 more source

CLINICAL AND HORMONAL MILIEU OF 9 PATIENTS WITH PRIMARY GROWTH HORMONE INSENSITIVITY SYNDROME AND THEIR RESPONSE TO IGF-I GENERATION TEST [PDF]

Acta Medica Iranica, 2006
Primary growth hormone insensitivity syndrome (GHIS) is a rare entity which can be due to defects in growth hormone (GH) receptor that is called type 1 Laron syndrome (T1LS) or post receptor defects (type 2 Laron syndrome ).
M. Razzaghy-Azar, M. Nourbakhsh F. Hajighasemi   +1 more
doaj   +2 more sources