Results 71 to 80 of about 3,629,719 (185)

Identification of UDP-Glucuronosyltransferase 2B15 (UGT2B15) as a Target for IGF1 and Insulin Action

Cells, 2022
Normal growth and development in mammals are tightly controlled by numerous genetic factors and metabolic conditions. The growth hormone (GH)-insulin-like growth factor-1 (IGF1) hormonal axis is a key player in the regulation of these processes ...
Rive Sarfstein, Karthik Nagaraj, Shivang Parikh, Carmit Levy, Zvi Laron, Dafna Benayahu, Haim Werner   +6 more
doaj   +1 more source

Growth curves for Laron syndrome. [PDF]

Archives of Disease in Childhood, 1993
Growth curves for children with Laron syndrome were constructed on the basis of repeated measurements made throughout infancy, childhood, and puberty in 24 (10 boys, 14 girls) of the 41 patients with this syndrome investigated in our clinic. Growth retardation was already noted at birth, the birth length ranging from 42 to 46 cm in the 12/20 available ...
Z, Laron, P, Lilos, B, Klinger
openaire   +2 more sources

Midlife Growth Hormone Receptor Ablation Extends Healthy Lifespan and Induces Sex‐Specific Hepatic Transcriptional Changes at Single‐Cell Resolution

Aging Cell, Volume 25, Issue 9, September 2026.
Reducing growth hormone receptor signaling beginning in middle age is sufficient to extend lifespan in both sexes while preserving metabolic and physical function, particularly in males. Single‐nucleus RNA sequencing reveals sex‐specific hepatic transcriptional remodeling associated with these longevity benefits. ABSTRACT Suppression of growth hormone (
Silvana Duran‐Ortiz, Edward O. List, Jonathan A. Young, Yuji Ikeno, Shouan Zhu, Todd McHugh, Patrick M. O'Connor, Minhoo Kim, Bérénice A. Benayoun, Fabian Benencia, Reetobrata Basu, Emmanuel A. Gotte, Darlene E. Berryman, John J. Kopchick   +13 more
wiley   +1 more source

Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP

Cells, 2022
The growth hormone (GH)–insulin-like growth factor-1 (IGF1) signaling pathway plays a major role in orchestrating cellular interactions, metabolism, growth and aging.
Karthik Nagaraj, Rive Sarfstein, Zvi Laron, Haim Werner   +3 more
doaj   +1 more source

Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators

Aging Cell, Volume 25, Issue 4, April 2026.
Terbinafine and miglustat are mitohormetic compounds that extend lifespan and healthspan. In C. elegans, these FDA‐approved drugs engage both ATFS‐1 and DAF‐16, highlighting a stress‐dependent coordination between mitochondrial and IIS pathways distinct from canonical IIS activation, relevant for healthy aging.
Amélia Lalou, Ioanna Daskalaki, Ilias Gkikas, Sandra Rodríguez‐López, Jean‐David Morel, Giorgia Benegiamo, Adrien Faure, Arwen W. Gao, Joaquim Barmaz, Qi Wang, Terytty Yang Li, Feng Gao, Danaé Broustail, Kristina Schoonjans, Giovanni D'Angelo, Johan Auwerx   +15 more
wiley   +1 more source

Growth hormone insensitivity syndrome: A sensitive approach

Indian Journal of Endocrinology and Metabolism, 2012
Patients with Growth Hormone Insensitivity have characteristic phenotypic features and severe short stature. The underlying basis are mutations in the growth hormone receptor gene which gives rise to a characteristic hormonal profile.
Soumik Goswami, Sujoy Ghosh, Subhankar Chowdhury   +2 more
doaj   +1 more source

Functional changes of the liver in the absence of growth hormone (GH) action – Proteomic and metabolomic insights from a GH receptor deficient pig model

Molecular Metabolism, 2020
Objective: The liver is a central target organ of growth hormone (GH), which stimulates the synthesis of insulin-like growth factor 1 (IGF1) and affects multiple biochemical pathways.
Evamaria O. Riedel, Arne Hinrichs, Elisabeth Kemter, Maik Dahlhoff, Mattias Backman, Birgit Rathkolb, Cornelia Prehn, Jerzy Adamski, Simone Renner, Andreas Blutke, Martin Hrabĕ de Angelis, Martin Bidlingmaier, Jochen Schopohl, Georg J. Arnold, Thomas Fröhlich, Eckhard Wolf   +15 more
doaj   +1 more source

Challenges of Access to Treatments: The Case Of Laron Syndrome and the Fight For Social Inclusion

Revista de Gestão Social e Ambiental
Objective: To identify and disseminate the challenges faced by patients with Laron syndrome in accessing Mecasermin treatment in Ecuador.   Theoretical Framework: Laron syndrome is a rare genetic disease characterised by metabolic disorders such as ...
G. Vasco-Toapanta, A. Guanoluisa-Vasco, Gabriela Alejandra Ochoa-Núñez, C. Vasco-Toapanta   +3 more
semanticscholar   +1 more source

Addition of Multi‐Level Technologies to Evaluate Eggs and Embryos and Improve Endometrial Quality Applied for In Vitro Fertilization to Achieve Pregnancy: A Case Study

Clinical Case Reports, Volume 14, Issue 3, March 2026.
This integrated clinical approach optimizes the reproductive cycle in several steps, starting with nutrition (A): restricting carbohydrates and inducing ketosis to reduce inflammation and improve insulin sensitivity, which benefits follicular development.
Tania G. Rojas‐Pérez, Yúvika Reyes‐Albarracín, Ginna Ortiz, Juan José Suárez, Diego Vilchis Reyes, Jacqueline Cordero Oropeza, Dinorah Hernández‐Melchor, Esther López‐Bayghen   +7 more
wiley   +1 more source

Anthropological characteristics of individuals of the IX–XI centuries from the monument of Dvin (Armenia) with growth disorders

Вестник археологии, антропологии и этнографии, 2017
Irrespective of era and habitat, people paid more attention to extraordinary and unlike phenomena, than to everywhere found and usual ones. This article is about unusual individuals of the 9th–11th centuries from Dvin, among which traces of delay of ...
Khudaverdyan A.Yu., Hakopyan N.G., Zhamkochyan А.S., Engibaryan A.A., Hovanisyan А.А.   +4 more
doaj   +1 more source