Results 61 to 70 of about 3,629,719 (185)
A CLINICAL CASE OF LARON SYNDROME IN THREE SIBLINGS
Мать и дитя в Кузбассе, 2022 Laron syndrome (Laron dwarfism) is a rare genetic disease with an autosomal recessive type of inheritance caused by defects in the somatotropic hormone receptor gene (GHR gene), leading to insensitivity of peripheral tissues to growth hormone.
Яна Вячеславовна Юнкина +3 more
doaj
Short stature related to Growth Hormone Insensitivity (GHI) in childhood
Frontiers in Endocrinology, 2023 Linear growth during childhood is the result of the synergic contribution of different factors. The best growth determinant system during each period of life is represented by the growth hormone–insulin-like growth factor axis (GH–IGF), even if several ...
Concetta Mastromauro +4 more
doaj +1 more source
Musculoskeletal Effects of Altered GH Action
Frontiers in Physiology, 2022 Growth hormone (GH) is a peptide hormone that can signal directly through its receptor or indirectly through insulin-like growth factor 1 (IGF-1) stimulation.
Jonathan A. Young +8 more
doaj +1 more source
Spectrum of Growth Hormone Disorders in Children: A Case Series of 5 Cases [PDF]
Journal of Clinical and Diagnostic Research, 2023 Growth Hormone Deficiency (GHD) is one of the most important treatable endocrine causes of short stature. A problem anywhere in the Growth Hormone (GH) - Insulin-Like Growth Factor-1 (IGF-1) axis can lead to short stature.
Anshuman +4 more
doaj +1 more source
PLoS ONE, 2013 The origin of hominins found on the remote Indonesian island of Flores remains highly contentious. These specimens may represent a new hominin species, Homo floresiensis, descended from a local population of Homo erectus or from an earlier (pre-H ...
Karen L Baab +2 more
doaj +1 more source
Nutrition & Metabolism, 2011 The insulin/insulin-like growth factor-1 (IGF-1) pathway drives an evolutionarily conserved network that regulates lifespan and longevity. Individuals with Laron syndrome who carry mutations in the growth hormone receptor (GHR) gene that lead to severe ...
Schmitz Gerd, John Swen, Melnik Bodo C
doaj +1 more source
Why Are People With Laron Syndrome Immune to Cancer? [PDF]
, 2015 Laron syndrome is a congenital autosomal recessive disorder that is caused by a mutation in the growth hormone receptor. People with this syndrome have an insensitivity to growth hormone.
Margolis, Raquel
core +1 more source
Same Phenotype in Children with Growth Hormone Deficiency and Resistance
Case Reports in Pediatrics, 2018 By definition, about 2.5% of children show a short stature due to several causes. Two clinical conditions are characterized by serum IGF-I low levels, idiopathic GH deficiency (IGHD), and GH insensitivity (GHI), and the phenotypic appearance of these ...
Irene Ioimo +4 more
doaj +1 more source
Growth hormone insensitivity: Mexican case report
Endocrinology, Diabetes & Metabolism Case Reports, 2017 Herein, we present a 14-year-old patient with short stature (134 cm) referred from Paediatrics to our department for complementary evaluation since growth hormone (GH) treatment failed to show any improvement.
I Castilla-Cortazar +6 more
doaj +1 more source
Journal of Anatomy, EarlyView.Our μCT‐based pilot study reveals size and shape disparity in the adult postcranial skeleton of growth‐hormone model (bGH) mice relative to wild‐type mice. bGH mice have larger and more sexually dimorphic bones, with a systemic radiodensity increase in bony sesamoids and associated, but typically uncalcified, soft tissues.
Joseph R. Groenke +7 more
wiley +1 more source