Results 91 to 100 of about 3,629,719 (185)

Structural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland: Lessons from a translational pig model

Journal of Neuroendocrinology, Volume 36, Issue 7, July 2024.
Abstract Growth hormone receptor deficiency (GHRD) results in low serum insulin‐like growth factor 1 (IGF1) and high, but non‐functional serum growth hormone (GH) levels in human Laron syndrome (LS) patients and animal models. This study investigated the quantitative histomorphological and molecular alterations associated with GHRD.
Bachuki Shashikadze, Sophie Franzmeier, Isabel Hofmann, Martin Kraetzl, Florian Flenkenthaler, Andreas Blutke, Thomas Fröhlich, Eckhard Wolf, Arne Hinrichs   +8 more
wiley   +1 more source

Five cases with Laron syndrome: Clinical and molecular evaluation

, 2016
Laron Syndrome is defined as primary growth hormone resistance or insensitivity. Our aim is to discuss the clinical, laboratory findings and growth hormone receptor gene mutation analysis of the Laron Syndrome cases.
Şükran Darcan, Korkmaz, Ozlem, Darcan, Sukran, Afig Berdeli, Goksen, Damla, Merve Tosyalı, Damla Gökşen, Tosyali, Merve, Özlem Korkmaz, Berdeli, Afig   +9 more
core   +1 more source

Challenges in the care of individuals with severe primary insulin-like growth factor-I deficiency (SPIGFD): an international, multi-stakeholder perspective

Orphanet Journal of Rare Diseases, 2023
Background Severe primary insulin-like growth factor-I (IGF-I) deficiency (SPIGFD) is a rare growth disorder characterized by short stature (standard deviation score [SDS] ≤ 3.0), low circulating concentrations of IGF-I (SDS ≤ 3.0), and normal or ...
Philippe F. Backeljauw, Mary Andrews, Peter Bang, Leo Dalle Molle, Cheri L. Deal, Jamie Harvey, Shirley Langham, Elżbieta Petriczko, Michel Polak, Helen L. Storr, Mehul T. Dattani   +10 more
doaj   +1 more source

Gut microbiota in regulation of childhood bone growth

Experimental Physiology, Volume 109, Issue 5, Page 662-671, 1 May 2024.
Abstract Childhood stunting and wasting, or decreased linear and ponderal growth associated with undernutrition, continue to be a major global public health challenge. Although many of the current therapeutic and dietary interventions have significantly reduced childhood mortality caused by undernutrition, there remain great inefficacies in improving ...
Julian C. Lui
wiley   +1 more source

LARON SYNDROME: A CASE REPORT

JMS SKIMS, 2017
Aim: The purpose of this case report is to define oral-dental findings of Laron Syndrome. Laron syndrome, is a very rare familiar disorder with autosomal recessive transition. Case Report: A 11-year-old patient applied to Marmara University Faculty of Dentistry for dental treatment. She had growth inadequacy, small face and high pitched voice which are
Shariq Rashid Masoodi, Mona Sood, Hilal Bhat, Moomin Hussain Bhat, Javaid Ahmad Bhat   +4 more
openaire   +3 more sources

Spatially segregated defects and IGF1‐responsiveness of hilar and peripheral biliary organoids from a model of Alagille syndrome

Liver International, Volume 44, Issue 2, Page 541-558, February 2024.
Abstract Background & Aims Alagille syndrome (ALGS) manifests with peripheral intrahepatic bile duct (IHBD) paucity, which can spontaneously resolve. In a model for ALGS, Jag1Ndr/Ndr mice, this occurs with distinct architectural mechanisms in hilar and peripheral IHBDs.
Afshan Iqbal, Noemi Van Hul, Lenka Belicova, Agustin A. Corbat, Simona Hankeova, Emma R. Andersson   +5 more
wiley   +1 more source

Annual banned‐substance review 16th edition—Analytical approaches in human sports drug testing 2022/2023

Drug Testing and Analysis, Volume 16, Issue 1, Page 5-29, January 2024.
Abstract In this 16th edition of the annual banned‐substance review on analytical approaches in human sports drug testing, literature on recent developments in this particular section of global anti‐doping efforts that was published between October 2022 and September 2023 is summarized and discussed.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

LARON SYNDROME. (Growth Hormone Insensitivity) Geographical distribution and relationship to the genetic defects in the growth hormone receptor gene.

Journal of Clinical Endocrinology and Metabolism
BACKGROUND Laron Syndrome (LS), caused by defects in the GH receptor (GH-R) gene, is a rare recessively inherited disease of severe short stature. The number of patients with LS worldwide is so far unknown.
T. Rabin, Y. Shinar, Z. Laron
semanticscholar   +1 more source

Molecular crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of granulosa cell function

Reproductive Medicine and Biology, Volume 23, Issue 1, January/December 2024.
Crosstalk between insulin‐like growth factors and follicle‐stimulating hormone in the regulation of ovarian antral follicles. Abstract Background The last phase of folliculogenesis is driven by follicle‐stimulating hormone (FSH) and locally produced insulin‐like growth factors (IGFs), both essential for forming preovulatory follicles.
Emily Hayes, Nicola Winston, Carlos Stocco   +2 more
wiley   +1 more source

The Effect of Endotoxin‐Induced Inflammation on the Activity of the Somatotropic Axis in Sheep

International Journal of Inflammation, Volume 2024, Issue 1, 2024.
The hypothalamic‐pituitary‐somatotropic (HPS) axis controls many physiological and pathophysiological processes. The phenomenon of insensitivity to growth hormone resistance (GHres) was previously reported to be due to the development of inflammation.
Maciej Wójcik, Dorota Anna Zieba, Joanna Bochenek, Agata Krawczyńska, Marcin Barszcz, Alina Gajewska, Hanna Antushevich, Andrzej Przemysław Herman, Mariusz Sikora   +8 more
wiley   +1 more source