Results 91 to 100 of about 4,378 (208)

EAPH-09. POTENT CLINICAL AND RADIOLOGICAL RESPONSE TO LAROTRECTINIB IN FIRST CASE OF TRK FUSION HIGH GRADE GLIOMA [PDF]

, 2018
David S. Ziegler, Maria Tsoli, Vanessa Tyrell, Richard J. Cohn, Loretta M. S. Lau, Michael C. Cox, Mark J. Cowley, Paul G. Ekert, Glenn M. Marshall, Michelle Haber   +9 more
openalex   +1 more source

HGG-09. FIRST LINE THERAPY OF PEDIATRIC GLIOBLASTOMA WITH LAROTRECTINIB [PDF]

, 2020
Musa Alharbi, Nahla Ali Mobark, Ali Abdullah O Balbaid, Fatmah A Alanazi, Wael abdel Rahman Aljabarat, Eman Bakhsh, Murad Turkistani, Malak Abedalthagafi   +7 more
openalex   +1 more source

Activity of larotrectinib in TRK fusion lung cancer [PDF]

, 2019
Alexander Drilon, Shivaani Kummar, Vı́ctor Moreno, Jyoti D. Patel, Ulrik Lassen, Lee S. Rosen, Barrett H. Childs, Shivani Nanda, M.C. Cox, N. Ku, Anna F. Farago   +10 more
openalex   +1 more source

Adaptive Darwinian off-target resistance mechanisms to selective RET inhibition in RET driven cancer

npj Precision Oncology
Patients treated with RET protein tyrosine kinase inhibitors (TKIs) selpercatinib or pralsetinib develop RET TKI resistance by secondary RET mutations or alterative oncogenes, of which alterative oncogenes pose a greater challenge for disease management ...
Vivek Subbiah, Mohamed A. Gouda, J. Bryan Iorgulescu, Ramona Dadu, Keyur Patel, Steven Sherman, Maria Cabanillas, Mimi Hu, Luz E. Castellanos, Behrang Amini, Funda Meric-Bernstam, Tao Shen, Jie Wu   +12 more
doaj   +1 more source

The First Case Treated with Larotrectinib of a Novel TMTC2-NTRK3 Fusion Undifferentiated High-Grade Pleomorphic Sarcoma of the Chest [PDF]

, 2021
Chujie Bai, Lu Zhang, Yaohui Wang, Taiyan Guo, Xia You, Zhengfu Fan   +5 more
openalex   +1 more source

Efficacy of Larotrectinib in TRK Fusion–Positive Cancers in Adults and Children

New England Journal of Medicine, 2018
A. Drilon, T. Laetsch, S. Kummar, S. DuBois, U. Lassen, G. Demetri, M. Nathenson, R. Doebele, A. Farago, A. Pappo, B. Turpin, A. Dowlati, M. Brose, L. Mascarenhas, N. Federman, J. Berlin, W. El-Deiry, C. Baik, J. Deeken, V. Boni, R. Nagasubramanian, Matthew H. Taylor, E. Rudzinski, F. Meric-Bernstam, D. Sohal, P. Ma, L. Raez, J. Hechtman, R. Benayed, M. Ladanyi, Brian B. Tuch, K. Ebata, S. Cruickshank, N. Ku, M. Cox, D. Hawkins, D. Hong, D. Hyman   +37 more
semanticscholar   +1 more source

HGG-15. SUCCESSFUL TREATMENT OF AN NTRK-FUSION POSITIVE INFANTILE GLIOBLASTOMA WITH LAROTRECTINIB, A TARGETED TRK INHIBITOR [PDF]

, 2019
Robin Buerki, Anuradha Banerjee, Alexandra Zamorski, Michael C. Cox, Shannon Raber, David A. Solomon, Sabine Mueller   +6 more
openalex   +1 more source

The landscape of cancer-associated transcript fusions in adult brain tumors: a longitudinal assessment in 140 patients with cerebral gliomas and brain metastases

Frontiers in Oncology
BackgroundOncogenic fusions of neurotrophic receptor tyrosine kinase NTRK1, NTRK2, or NTRK3 genes have been found in different types of solid tumors.
Philippe Metellus, Philippe Metellus, Clara Camilla, Clara Camilla, Emilie Bialecki, Nathalie Beaufils, Christine Vellutini, Eric Pellegrino, Pascale Tomasini, Pascale Tomasini, Manmeet S. Ahluwalia, Manmeet S. Ahluwalia, Alireza Mansouri, Isabelle Nanni, L’Houcine Ouafik, L’Houcine Ouafik   +15 more
doaj   +1 more source

NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors

Acta Neuropathologica Communications
Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they are tissue agnostic and cross the blood ...
Eric Eunshik Kim, Chul-Kee Park, Seung-Ki Kim, Ji Hoon Phi, Sun Ha Paek, Jung Yoon Choi, Hyoung Jin Kang, Joo Ho Lee, Jae Kyung Won, Hongseok Yun, Sung-Hye Park   +10 more
doaj   +1 more source

Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study

, 2018
Theodore W. Laetsch, Steven G. DuBois, Leo Mascarenhas, Brian Turpin, Noah Federman, Catherine M. Albert, Ramamoorthy Nagasubramanian, Jessica L. Davis, Erin R. Rudzinski, Angela M. Feraco, Brian B. Tuch, Kevin Ebata, Mark Reynolds, Steven G. Smith, Scott Cruickshank, Michael C. Cox, Alberto S. Pappo, Douglas S. Hawkins   +17 more
openalex   +2 more sources