Results 81 to 90 of about 4,378 (208)

PD-28 Long-term efficacy and safety of larotrectinib in patients with tropomyosin receptor kinase (TRK) fusion gastrointestinal (GI) cancer: An updated analysis [PDF]

, 2023
Thierry André, David S. Hong, John F. Deeken, Antoîne Italiano, Tianshu Liu, Domnita-Ileana Burcoveanu, Ricarda Norenberg, Chiara Mussi, Rui‐Hua Xu, Alexander Drilon, Lin Shen   +10 more
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Estimating Long-Term Survival Outcomes for Tumor-Agnostic Therapies: Larotrectinib Case Study [PDF]

, 2021
Andrew Briggs, Noman Paracha, Katherine L. Rosettie, Alexander J. Upton, Carsten Bokemeyer, Ulrik Lassen, Sean D. Sullivan   +6 more
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Predictors of radioiodine (RAI)-avidity restoration for NTRK fusion-positive RAI-resistant metastatic thyroid cancers

European Thyroid Journal
Context: Two-thirds of metastatic differentiated thyroid cancer (DTC) patients have radioiodine (RAI)-resistant disease, resulting in poor prognosis and high mortality.
Abdul Rehman Syed, Aakash Gorana, Erik Nohr, Xiaoli-Kat Yuan, Parthiv Amin MASc, Sana Ghaznavi, Debbie Lamb, John McIntyre, Markus Eszlinger, Ralf Paschke   +9 more
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CTNI-75. EFFICACY AND SAFETY OF LAROTRECTINIB IN PATIENTS WITH TROPOMYOSIN RECEPTOR KINASE (TRK) FUSION PRIMARY CENTRAL NERVOUS SYSTEM (CNS) TUMORS: AN UPDATED ANALYSIS [PDF]

, 2023
Sébastien Perreault, François Doz, Birgit Geoerger, Antoîne Italiano, Ulrik Lassen, Anna Nilsson, Karsten Nysom, Jean-Philippine Spano, Ricarda Norenberg, Vadim Bernard-Gauthier, Esther De La Cuesta, Alexander Drilon, Theodore W. Laetsch, Cornelis van Tilburg   +13 more
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Precision medicine and its implementation in patients with NTRK fusion genes: perspective from developing countries

Therapeutic Advances in Respiratory Disease, 2020
Precision oncology is the field that places emphasis on the diagnosis and treatment of tumors that harbor specific genomic alterations susceptible to inhibition or modulation.
Andrés F. Cardona, Oscar Arrieta, Alejandro Ruiz-Patiño, Carolina Sotelo, Nataly Zamudio-Molano, Zyanya Lucia Zatarain-Barrón, Luisa Ricaurte, Luis Raez, Marco Polo Peralta Álvarez, Feliciano Barrón, Leonardo Rojas, Christian Rolfo, Niki Karachaliou, Miguel Angel Molina-Vila, Rafael Rosell   +14 more
doaj   +1 more source

Metabolic Stability Assessment of Larotrectinib Using Liquid Chromatography Tandem Mass Spectrometry

Drug Design, Development and Therapy, 2020
Mohamed W Attwa, 1, 2 Adnan A Kadi, 1 Hany W Darwish 1, 3 1Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia; 2Students’ University Hospital, Mansoura University, Mansoura 35516, Egypt;
Attwa MW, Kadi AA, Darwish HW
doaj  

465P Larotracking: Real-life study of locally advanced/metastatic solid tumor treated with larotrectinib in French expanded access program [PDF]

, 2022
Armelle Dufresne, Olivier Huillard, Cécile Dalban, Margaux Geier, J. Wassermann, Sylvie Zanetta, M. Cabourg, Bogdan Catargi, C. El Kouri, I. Hrab, M. Laramas, A. Moreira, Esma Saâda, C. Tournigand, Thibaud Valentin, Élodie Vauléon, Romaine Mayet, David Pérol, Jean‐Yves Blay   +18 more
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Targeting nerve growth factor-mediated osteosarcoma metastasis: mechanistic insights and therapeutic opportunities using larotrectinib

Cell Death and Disease
Osteosarcoma (OS) therapy presents numerous challenges, due largely to a low survival rate following metastasis onset. Nerve growth factor (NGF) has been implicated in the metastasis and progression of various cancers; however, the mechanism by which NGF
Chun-Han Hou, Wei-Li Chen, Chih-Yang Lin
semanticscholar   +1 more source

Larotrectinib versus Prior Therapies in Tropomyosin Receptor Kinase Fusion Cancer: An Intra-Patient Comparative Analysis [PDF]

, 2020
Antoîne Italiano, Shivani Nanda, Andrew Briggs, Jesús García‐Foncillas, Ulrik Lassen, Gilles Vassal, Shivaani Kummar, Cornelis M. van Tilburg, David S. Hong, Theodore W. Laetsch, Karen Keating, John A. Reeves, Marc Fellous, Barrett H. Childs, Alexander Drilon, David M. Hyman   +15 more
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Nerve growth factor promote VCAM-1-dependent monocyte adhesion and M2 polarization in osteosarcoma microenvironment: Implications for larotrectinib therapy

International Journal on Biological Sciences
Osteosarcoma is the most prevalent form of primary malignant bone tumor, primarily affecting children and adolescents. The nerve growth factors (NGF) referred to as neurotrophins have been associated with cancer-induced bone pain; however, the role of ...
Syuan-Ling Lin, Shang-Yu Yang, Chun-Hao Tsai, Y. Fong, Wei-Li Chen, Ju-Fang Liu, Chih-Yang Lin, Chih-Hsin Tang   +7 more
semanticscholar   +1 more source