Results 71 to 80 of about 4,449,071 (303)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Laser acceleration of monoenergetic protons via a double layer emerging from an ultra-thin foil [PDF]
, 2009 We present theoretical and numerical studies of the acceleration of monoenergetic protons in a double layer formed by the laser irradiation of an ultra-thin film.
Shukla, Padma K. +4 more
core +4 more sources
npj Computational MaterialsFirst-principles electron dynamics calculations can be applied in the investigation of a wide range of ultrafast phenomena in attosecond physics. They offer unique microscopic insight into light-induced ultrafast phenomena in both gas and condensed ...
Shunsuke A. Sato +3 more
doaj +1 more source
Nonthermal phase transitions in semiconductors induced by a femtosecond extreme ultraviolet laser pulse [PDF]
, 2013 Part of Focus on High Energy Density Physics. In this paper, we present a novel theoretical approach, which allows the study of nonequilibrium dynamics of both electrons and atoms/ions within free-electron laser excited semiconductors at femtosecond time
Jeschke, H. O. +3 more
core +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Phonon-driven spin-Floquet magneto-valleytronics in MoS2
Nature Communications, 2018 In 2H semiconducting transition-metal dichalcogenides the valley-selective excitation has been achieved with circularly polarized photons. Here, the authors show that circularly polarized phonons produce a valley-dependent dynamic spin state as a result ...
Dongbin Shin +5 more
doaj +1 more source
Solution structure and dynamics of a semiconductor laser subject to feedback from two external filters [PDF]
, 2010 We present an analysis of a semiconductor laser subject to filtered optical feedback from two filtering elements (2FOF). The motivation for this study comes from applications where two filters are used to control and stabilise the laser output.
Slowinski, P. +4 more
core
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Enhanced high harmonic efficiency through phonon-assisted photodoping effect
npj Computational MaterialsHigh-harmonic generation (HHG) has emerged as a central technique in attosecond science and strong-field physics, providing a tool for investigating ultrafast dynamics.
Jin Zhang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source