Results 91 to 100 of about 17,001 (224)

Strategic Preparedness of Broad‐Spectrum Antivirals for Rapid Response Towards Next Pandemics

Small Science, Volume 6, Issue 1, January 2026.
Nanoengineered broad‐spectrum antivirals (BSAs) represent a transformative approach to pandemic preparedness. Unlike virus‐specific drugs requiring separate development, BSAs act across multiple viral families through nanoengineering strategies that enhance solubility, bioavailability, and host‐targeted activity.
Sanoj Rejinold N, Geun‐woo Jin, Jin‐Ho Choy   +2 more
wiley   +1 more source

Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa fever. [PDF]

, 2015
BACKGROUND: Zoonotic infections, which transmit from animals to humans, form the majority of new human pathogens. Following zoonotic transmission, the pathogen may already have, or may acquire, the ability to transmit from human to human. With infections
Cunningham, Andrew A, Fichet-Calvet, Elisabeth, Garry, Robert F, Grant, Donald S, Khan, Sheik Humarr, Leach, Melissa, Lo Iacono, Giovanni, Moses, Lina M, Schieffelin, John S, Shaffer, Jeffrey G, Webb, Colleen T, Wood, James LN   +11 more
core   +4 more sources

Views of Health Professionals on the Contribution of Climate Change to the Transmission of Lassa Fever in Nigeria and the Implications for Risk Communication

Advances in Public Health, Volume 2026, Issue 1, 2026.
Lassa fever is an acute viral haemorrhagic illness caused by the Lassa virus and is mainly spread through direct and indirect human–rodent interaction. In Nigeria, Lassa fever outbreaks are becoming more frequent, and studies suggest that changes in climatic and ecological conditions will exacerbate these trends. It is crucial that health professionals
Ibrahim Yusuf Eroje, Richard Philip Lee, Hannah Wesley   +2 more
wiley   +1 more source

Prevalence of Lassa virus among rodents trapped in three South-South States of Nigeria

Journal of Vector Borne Diseases, 2017
Background & objectives: Lassa fever has been endemic in Nigeria since 1969. The rodent Mastomys natalensis has been widely claimed to be the reservoir host of the Lassa virus.
D E Agbonlahor, A Erah, I M Agba, F E Oviasogie, A F Ehiaghe, M Wankasi, O A Eremwanarue, I J Ehiaghe, E C Ogbu, R I Iyen, S Abbey, M Y Tatfeng, J Uhunmwangho   +12 more
doaj  

Some Remarks about the Complexity of Epidemics Management

, 2017
Recent outbreaks of Ebola, H1N1 and other infectious diseases have shown that the assumptions underlying the established theory of epidemics management are too idealistic. For an improvement of procedures and organizations involved in fighting epidemics,
Brown, André EX, Ch'ng, Quee-Lim, Currie, Michael, Grundy, Laura J, Hokanson, Jim, Javer, Avelino, Kerr, Rex, Lee, Chee Wai, Li, Chris, Li, Kezhi, Schafer, William R, Yemini, Eviatar   +11 more
core   +4 more sources

Experimental Zika Virus Infection in the Pregnant Common Marmoset Induces Spontaneous Fetal Loss and Neurodevelopmental Abnormalities. [PDF]

, 2018
During its most recent outbreak across the Americas, Zika virus (ZIKV) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women.
Aagaard, Kjersti M, Castro, Eumenia CC, Chiu, Charles Y, Giavedoni, Luis, Hodara, Vida L, Layne-Colon, Donna, Li, Tony, Martyn, Calla, Parodi, Laura M, Patterson, Jean L, Reyes, Kevin, Rutherford, Julienne, Seferovic, Maxim, Suter, Melissa A, Sánchez-San Martín, Claudia, Tamhankar, Manasi, Tardif, Suzette D, Yagi, Shigeo   +17 more
core   +2 more sources

Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism

BioMed Research International, Volume 2026, Issue 1, 2026.
The cross‐reactivity of substrates, modulators with other enzymes significantly reduces/prevents our ability to design such highly specific, that is, “one warhead–one target”, modulators. On the other hand, the potential “impasse” fuels repurposing of already developed drugs.
Monika I. Konaklieva, Balbina J. Plotkin, Nahit Gencer   +2 more
wiley   +1 more source

Need for Aeromedical Evacuation High-Level Containment Transport Guidelines [PDF]

, 2019
Circumstances exist that call for the aeromedical evacuation high-level containment transport (AE-HLCT) of patients with highly hazardous communicable diseases.
Achutan, Chandran, Beam, Elizabeth L., Carter, Gary W., Cieslak, Theodore J., Gibbs, Shawn G., Herstein, Jocelyn J., Kopocis-Herstein, Kelli R., Lawler, James V., Le, Aurora B., Lowe, John J., Santarpia, Joshua L., Stentz, Terry L.   +11 more
core   +1 more source

Therapeutic antibodies: current state and future trends--is a paradigm change coming soon? [PDF]

, 2008
Antibody-based therapeutics currently enjoy unprecedented success, growth in research and revenues, and recognition of their potential. It appears that the promise of the "magic bullet" has largely been realized.
Dimitrov, Dimiter S, Marks, James D
core   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen, Chenhao Che, Lingjie Wu, Changjie Sun, Dongming Xu, Qinyang Hua, Yunzhong Zhang, Yi‐Quan Tang, Peng Shi, Shan Sun   +9 more
wiley   +1 more source