Results 81 to 90 of about 17,001 (224)

Immunobiology of Ebola and Lassa virus infections [PDF]

Nature Reviews Immunology, 2017
Two of the most important contemporary emerging viruses that affect human health in Africa are Ebola virus (EBOV) and Lassa virus (LASV). The 2013-2016 West African outbreak of EBOV was responsible for more than 11,000 deaths, primarily in Guinea, Sierra Leone and Liberia.
Joseph B, Prescott, Andrea, Marzi, David, Safronetz, Shelly J, Robertson, Heinz, Feldmann, Sonja M, Best   +5 more
openaire   +2 more sources

Detection of Antibody and Antigen for Lassa Virus Nucleoprotein in Monkeys from Southern Nigeria

Journal of Epidemiology and Global Health, 2019
Lassa fever is a deadly viral haemorrhagic fever caused by Lassa Virus (LASV). Rodents, especially, Mystomys natalensis, are the known reservoirs of LASV and humans are the defined hosts.
Bamidele Nyemike Ogunro, Babasola Oluseyi Olugasa, Adeyemi Kayode, Olayinka Olabisi Ishola, Oluseyi Noah Kolawole, Eugene Amiewanlen Odigie, Christian Happi   +6 more
doaj   +1 more source

Factors underlying Ebola virus infection among health workers, Kenema, Sierra Leone, 2014-2015 [PDF]

, 2016
Background. Ebola virus disease (EVD) in health workers (HWs) has been a major challenge during the 2014-2015 outbreak. We examined factors associated with Ebola virus exposure and mortality in HWs in Kenema District, Sierra Leone. Methods.
Bausch, Daniel G., Brett-Major, David M., Fowler, Robert A., French, Issa, Pratt, Christian, Pringle, Kimberly, Ramsay, Andrew, Saidu, Josephine, Sellu, Josephine, Senga, Mikiko, Shindo, Nahoko, Sierra Leone Kenema District Task Force and Kenema General Hospital, Vandi, Mohamed   +12 more
core   +3 more sources

The role of the gut microbiome in the regulation of high‐altitude adaptation

iMeta, Volume 5, Issue 1, February 2026.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang, Senlin Zhu, Michael Kreuzer, Shoukun Ji, Wei Wang, Yanliang Bi, Shengli Li   +6 more
wiley   +1 more source

Mutational Analysis of the Lassa Virus Promoter [PDF]

Journal of Virology, 2006
ABSTRACT The promoter sequences directing viral gene expression and genome replication of arenaviruses reside within the 3′ and 5′ termini of each RNA segment. The terminal 19 nucleotides at both ends are highly conserved among all arenavirus species and are almost completely complementary to each other. This study aimed at characterizing the
Meike, Hass, Martina, Westerkofsky, Stefanie, Müller, Beate, Becker-Ziaja, Carola, Busch, Stephan, Günther   +5 more
openaire   +2 more sources

Stampidine prevents mortality in an experimental mouse model of viral hemorrhagic fever caused by lassa virus

BMC Infectious Diseases, 2004
Background The potential use of microorganisms as agents of biological warfare (BW) is a growing concern. Lassa virus, a member of the Arenavirus class of Hemorrhagic fever (HF) viruses has emerged as a worldwide concern among public health officials ...
Tibbles Heather E, Vassilev Alexei O, Petkevich Alexander S, Uckun Fatih M, Titov Leonid   +4 more
doaj   +1 more source

Land use gradients drive spatial variation in Lassa fever host communities in the Eastern Province of Sierra Leone

Journal of Animal Ecology, Volume 95, Issue 2, Page 296-312, February 2026.
As West Africa urbanises, the risk of Lassa fever may paradoxically decrease. We found the invasive house mouse, a dominant urban species, outcompetes and displaces the primary Lassa virus host. Considering these species interactions is critical for accurately predicting future zoonotic disease patterns.
David Simons, Rory Gibb, Umaru Bangura, Dianah Sondufu, Joyce Lamin, James Koninga, Momoh Foday, Mike Dawson, Joseph Lahai, Rashid Ansumana, Elisabeth Fichet‐Calvet, Deborah Watson‐Jones, Richard Kock, Kate E. Jones   +13 more
wiley   +1 more source

Assessing the Environmental Drivers of Lassa Fever in West Africa: A Systematic Review

Viruses
The spread of Lassa virus in West Africa is reliant on the abundance and distribution of its rodent host reservoirs. While the impact of environmental change on viral spread has been studied for many zoonotic viruses, there is still a limited ...
Natalie A. Davis, Madeline A. Kenyon, Bruno M. Ghersi, Jessica L. Decker Sparks, Jonathon D. Gass   +4 more
doaj   +1 more source

A Systematic Review on the Economic Burden of the Most Prevalent Infectious Diseases in West Africa

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aim Infectious diseases, including malaria, tuberculosis, cholera, and Lassa fever, pose a significant public health and economic challenge in West Africa. The financial burden includes direct medical costs (hospitalization, medication, diagnostics), nonmedical costs (transportation, food, caregiving), and indirect costs (loss ...
Kofi Afriyie Nyamekye, Eric Sampane‐Donkor, Haruna Latif, Justice Moses K. Aheto   +3 more
wiley   +1 more source

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques

mBio, 2018
Lassa virus (LASV) causes a severe, often fatal hemorrhagic disease in regions in Africa where the disease is endemic, and approximately 30% of patients develop sudden-onset sensorineural hearing loss after recovering from acute disease.
Kathleen A. Cashman, Eric R. Wilkinson, Xiankun Zeng, Anthony P. Cardile, Paul R. Facemire, Todd M. Bell, Jeremy J. Bearss, Carl I. Shaia, Connie S. Schmaljohn   +8 more
doaj   +1 more source