Results 181 to 190 of about 10,303 (224)
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2020
Individuals living in endemic hotspots of Lassa fever have recurrent exposure to Lassa virus (LASV) via spillover from the primary host reservoir Mastomys natalensis. Despite M. natalensis being broadly distributed across sub-Saharan Africa, Lassa fever is only found in West Africa. In recent years, new LASV reservoirs have been identified.
Allison R, Smither +1 more
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Individuals living in endemic hotspots of Lassa fever have recurrent exposure to Lassa virus (LASV) via spillover from the primary host reservoir Mastomys natalensis. Despite M. natalensis being broadly distributed across sub-Saharan Africa, Lassa fever is only found in West Africa. In recent years, new LASV reservoirs have been identified.
Allison R, Smither +1 more
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2022
Lassa Fever (LF) is a viral hemorrhagic fever endemic in West Africa. LF begins with flu-like symptoms that are difficult to distinguish from other common endemic diseases such as malaria, dengue, and yellow fever making it hard to diagnose clinically.
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Lassa Fever (LF) is a viral hemorrhagic fever endemic in West Africa. LF begins with flu-like symptoms that are difficult to distinguish from other common endemic diseases such as malaria, dengue, and yellow fever making it hard to diagnose clinically.
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2017
The Old World (OW) arenavirus Lassa (LASV ) is estimated to infect several hundred thousand people yearly in West Africa, resulting in high numbers of Lassa fever (LF), a viral hemorrhagic fever (HF) disease associated with high morbidity and mortality.
Luis, MartÃnez-Sobrido +2 more
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The Old World (OW) arenavirus Lassa (LASV ) is estimated to infect several hundred thousand people yearly in West Africa, resulting in high numbers of Lassa fever (LF), a viral hemorrhagic fever (HF) disease associated with high morbidity and mortality.
Luis, MartÃnez-Sobrido +2 more
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Lassa Virus Hepatitis: a Study of Fatal Lassa Fever in Humans
The American Journal of Tropical Medicine and Hygiene, 1986In order to explore the significance of a previous observation that the most important pathologic changes in fatal Lassa fever are hepatic, we have studied postmortem liver biopsies from 19 patients with fatal Lassa fever. We observed a vigorous macrophage response to cellular damage, but we found no evidence of lymphocyte infiltration in infected ...
J B, McCormick +6 more
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Standardization of a plaque assay for lassa virus
Journal of Medical Virology, 1987AbstractThe plaque reduction neutralization test (PRNT) has been used routinely in serological studies with such arenaviruses as Junin, Machupo, and Parana. However, difficulties have been encountered in using the PRNT for LCM virus, while conflicting views have been expressed about the reliability and efficacy of the test with Lassa virus.
O, Tomori +3 more
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Lassa Virus Structural Biology and Replication
2023Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic fever that is endemic in West Africa. LASV virions are enveloped and contain two single-stranded RNA genome segments. Both segments are ambisense and encode two proteins. The nucleoprotein associates with viral RNAs forming ribonucleoprotein complexes. The glycoprotein
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Isolation and Antigenic Characterization of Lassa Virus
Nature, 1970LASSA fever as it was first noticed early in 1969 in three missionary nurses in Nigeria will be described by Frame et al.1. The disease later affected two laboratory workers at the Yale Arbovirus Research Unit (YARU) in New Haven. Two of the nurses and one of the laboratory workers died.
S M, Buckley, J, Casals, W G, Downs
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1973
Lassa fever is a virus disease of man characterized by generalized organ involvement resulting in manifestations of myositis, myocarditis, pneumonitis, encephalopathy, and signs of kidney involvement and hemorrhagic diathesis.
J. Casals, Sonja M. Buckley
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Lassa fever is a virus disease of man characterized by generalized organ involvement resulting in manifestations of myositis, myocarditis, pneumonitis, encephalopathy, and signs of kidney involvement and hemorrhagic diathesis.
J. Casals, Sonja M. Buckley
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Animal models for Lassa virus infection
Current Opinion in Virology, 2019In humans, Lassa virus infection can result in disease with hemorrhagic manifestations and high fatality rates. There are no approved treatments or vaccines available and the inherent danger of studying Lassa virus means it can only be studied in high containment labs (BSL4).
Tsing-Lee, Tang-Huau +2 more
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Studies of Lassa Virus Cell Entry
2017Host cell entry is the first and most fundamental step of every virus infection and represents a major barrier for zoonotic transmission and viral emergence. Targeting viral entry appears further as a promising strategy for therapeutic intervention. Several cellular receptors have been identified for Lassa virus, including dystroglycan, TAM receptor ...
Pasquato A, Fernandez AH, Kunz S
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