Results 61 to 70 of about 160,127 (291)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Three hundred eighty thousand year long stable isotope and faunal records from the Red Sea : influence of global sea level change on hydrography [PDF]

, 1996
Stable isotope and faunal records from the central Red Sea show high-amplitude oscillations for the past 380,000 years. Positive δ18O anomalies indicate periods of significant salt buildup during periods of lowered sea level when water mass exchange with
Ahuva Almogi-Labin, Almogi-Labin, Almogi-Labin, Almogi-Labin, Anati, Anderson, Assaf, Berger, Berggren, Bethoux, Bijma, Birgit Hiller, Bonnefille, Brachert, Bryden, Bryden, Chen, Christoph Hemleben, Clemens, Clemens, COHMAP Members, Craig, Deuser, Deuser, Dieter Meischner, Fairbanks, Gasse, Helmut Erlenkeuser, Herman, Imbrie, Ivanova, Jasper, Kutzbach, Kutzbach, Labeyrie, Lezine, Locke, Milliman, Morcos, Niitsuma, Pachur, Pachur, Prell, Prell, Prell, Rainer Zahn, Reiss, Risch, Rohling, Rossignol-Strick, Sirocko, Thunell, Yusuf, Zahn   +53 more
core   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Lower Glacial Oxygen in the Eastern Equatorial Pacific Concentrated in the Deep Sea

Geophysical Research Letters
Oxygen in the global oceans has declined since the 1960s, including in the Eastern Equatorial Pacific (EEP). Reconstructions of EEP glacial oxygenation help advance understanding of current and projected ocean deoxygenation.
Wanyi Lu, Delia W. Oppo, Xiaoying Jiang, Haowen Dang, Zhimin Jian   +4 more
doaj   +1 more source

The last glacial-interglacial cycle in Lake Ohrid (Macedonia/Albania): testing diatom response to climate [PDF]

, 2010
Lake Ohrid is a site of global importance for palaeoclimate research. This study presents results of diatom analysis of a ca. 136 ka sequence, Co1202, from the northeast of the lake basin.
Cvetkoska, A., Levkov, Z., Reed, J. M., Vogel, H., Wagner, B.   +4 more
core   +5 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Discharge of Meteoric Water in the Eastern Norwegian Sea since the Last Glacial Period

Geophysical Research Letters, 2019
Submarine groundwater discharge could impact the transport of critical solutes to the ocean. However, its driver(s), significance over geological time scales, and geographical coverage are poorly understood.
Wei‐Li Hong, Aivo Lepland, Tobias Himmler, Ji‐Hoon Kim, Shyam Chand, Diana Sahy, Evan A. Solomon, James W. B. Rae, Tõnu Martma, Seung‐Il Nam, Jochen Knies   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Landscape genetics reveal broad and fine‐scale population structure due to landscape features and climate history in the northern leopard frog (Rana pipiens) in North Dakota [PDF]

, 2018
Prehistoric climate and landscape features play large roles structuring wildlife populations. The amphibians of the northern Great Plains of North America present an opportunity to investigate how these factors affect colonization, migration, and current
Fisher, Justin D.L., Mushet, David M., Purcell, Kevin, Stockwell, Craig A., Waraniak, Justin M.   +4 more
core   +1 more source