Results 81 to 90 of about 14,197,112 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Profiles of Fatigue and Psychological Symptoms in Long‐Term Childhood, Adolescent, and Young Adult Cancer Survivors—The NOR‐CAYACS Study

Cancer Medicine
Introduction Long‐term childhood, adolescent, and young adult cancer survivors (CAYACS) are at risk of fatigue and psychological problems. However, their interactions remain largely unexplored.
Wei H. Deng, Hanne C. Lie, Ellen Ruud, Jon H. Loge, Cecilie E. Kiserud, Corina S. Rueegg   +5 more
doaj   +1 more source

Treatment of neuropathic pain in cancer survivors: a scoping review of pharmacological, exercise, and psychosocial interventions

Acta Oncologica
Background and purpose: Neuropathic pain is a debilitating late effect among cancer survivors. This scoping review aims to provide an overview of pharmacological, psychological, and exercise interventions for neuropathic pain among cancer survivors and ...
Ellen Lund Schaldemose, Bolette Skjødt Rafn, Pernille Envold Bidstrup, Agon Olloni, Katrin Schättiger, Peter Christensen, Cæcilie Borregaard Myrhøj, Maja Johannsen Lindberg, Christoffer Johansen, Sandra Jensen, Ida Hovdenak, Sasja Jul Håkonsen, Lise Ventzel   +12 more
doaj   +1 more source

Bone Mineral Turnover after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Single Center Cohort Study

Педиатрическая фармакология, 2018
Bone mineral metabolism disorders are one of the most frequent late complications after allogeneic hematopoietic stem cell transplantation (HSCT) in children.The aim of the study was to detect the incidence and risk factors for bone mineral metabolism ...
Yuliya V. Skvortsova, Dmitriy N. Balashov, Elena V. Skorobogatova, Zhanna B. Shekhovtsova, Kirill A. Voronin, Alexei A. Maschan   +5 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Late effects in children and adolescents after treatment for cancer

Improved survival among children and adolescents with cancer has increased the number of long-term survivors, including those who experience severe and complex late effects.
Hansen, Dorte; id_orcid, Dam, Merete Eybye, Buskbjerg, Cecilie Viola, Albertsen, Birgitte Klug, Rathe, Mathias; id_orcid, Skipper, Mette Tiedemann, Maraldo, Maja Vestmø, Lassen-Ramshad, Yasmin, Skeisvoll, Christina   +8 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Health-related quality of life among women diagnosed with in situ or invasive breast cancer and age-matched controls: a population-based study

Journal of Patient-Reported Outcomes
Purpose A breast cancer (BC) diagnosis may negatively affect health-related quality of life (HRQoL). However, there are few comparisons of HRQoL at several time points for women with BC, and particular when subdivided into invasive and in situ tumors ...
Synne K. H. Bøhn, Karianne Svendsen, A. Balto, Ylva Maria Gjelsvik, Tor Åge Myklebust, Elin Børøsund, Hege R. Eriksen, A. Meland, K. Østby, L. Solberg Nes, Cecilie E. Kiserud, Kristin V. Reinertsen, G. Ursin   +12 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Endocrine late effects of childhood cancer therapy

, 2010
Survival rates are improving following effective cancer therapy in childhood cancer. As the number of childhood cancer survivors increases, the late effects of cancer therapy are encountered more frequently.
Darendeliler, Emin, POYRAZOĞLU, Şükran, DARENDELİLER, Fatma Feyza, BAŞ, Firdevs   +3 more
core