Results 91 to 100 of about 178,686 (262)

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Last Glacial Maximum cooling induced positive moisture balance and maintained stable human populations in Australia

Communications Earth & Environment
Long-standing interpretations of the Last Glacial Maximum (21,000 ± 2000 years ago) in Australia suggest that the period was extremely cold and arid, during which the Indo-Australian summer monsoon system collapsed, and human populations declined and ...
Haidee Cadd, Alan N. Williams, Wanchese M. Saktura, Tim J. Cohen, Scott D. Mooney, Chengfei He, Bette Otto‐Bliesner, Chris S. M. Turney   +7 more
doaj   +1 more source

Significance of Hippophae rhamnoides L. in evolution of the Eemian Interglacial' flora in Warsaw area

Acta Societatis Botanicorum Poloniae, 2014
Palynologic studies of sediments from Warsaw-Wawrzyszew and other sites in the Warsaw Basin enabled to analyze main occurrence phases of Hippophae rhamnoides during the widely understood Lake Pleistocene interglacial warming.
Krzysztof M. Krupiński
doaj   +1 more source

South Asian monsoon history over the past 60 kyr recorded by radiogenic isotopes and clay mineral assemblages in the Andaman Sea [PDF]

, 2015
The Late Quaternary variability of the South Asian (or Indian) monsoon has been linked with glacial‐interglacial and millennial scale climatic changes but past rainfall intensity in the river catchments draining into the Andaman Sea remains poorly ...
Ali, Sajid, Frank, Martin, Gebregiorgis, Daniel, Giosan, Liviu, Hathorne, Ed C., Johnson, Joel E., Kutterolf, Steffen, Stattegger, Karl, Stumpf, Roland   +8 more
core   +1 more source

Northern Hemisphere Glaciation during the Globally Warm Early Late Pliocene [PDF]

, 2013
The early Late Pliocene (3.6 to ~3.0 million years ago) is the last extended interval in Earth's history when atmospheric CO2 concentrations were comparable to today's and global climate was warmer.
DeSchepper, Stijn, Groeneveld, J, Head, M, Hennissen, Jan, Karl, Fabian, Louwye, Stephen, Naafs, B D A, Renterghem, Cédéric   +7 more
core   +6 more sources

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Two Circumpolar Ground Beetle Species (Coleoptera: Carabidae) Were in Hokkaido, Japan, Late in the Last Glacial Period

Quaternary
Fossilized body parts of two cold-adapted ground beetle species, Elaphrus lapponicus and Diacheila polita, were identified from a deposit dated to the Late Glacial period in Hokkaido, Japan.
Shigehiko Shiyake
doaj   +1 more source

Development of the late glacial Baltic basin and the succession of vegetation cover as revealed at Palaeolake Haljala, northern Estonia [PDF]

Estonian Journal of Earth Sciences, 2009
The 4.5 m thick Haljala sequence in North Estonia was studied to provide information on palaeoenvironmental changes between 13 800 and 11 300 cal yr BP.
Saarse, Leili, Niinemets, Eve, Amon, Leeli, Heinsalu, Atko, Veski, Siim, Sohar, Kadri   +5 more
doaj  

A mild Younger Dryas recorded in southeastern Alaska

Arctic, Antarctic, and Alpine Research, 2020
Palynological and sedimentological analyses of lacustrine cores from Baker Island, located in southeastern Alaska’s Alexander Archipelago, indicate that the beginning of the Younger Dryas chronozone, between approximately 12,900 cal yr BP and ...
Paul S. Wilcox, Sarah J. Fowell, James F. Baichtal   +2 more
doaj   +1 more source

Syngenetic sand veins and anti-syngenetic sand wedges, Tuktoyaktuk Coastlands, western Arctic Canada [PDF]

, 2007
Sand-sheet deposits of full-glacial age in the Tuktoyaktuk Coastlands, western Arctic Canada, contain syngenetic sand veins 1-21 cm wide and sometimes exceeding 9 m in height.
Bateman, Bateman, Berg, Brookfield, Burn, Carter, Carter, Dallimore, Dinter, Dostovalov, Dylik, Environment Canada, French, French, Ghysels, Gozdzik, Harry, Hopkins, Julian B. Murton, Kasper, Kasse, Kocurek, Kolstrup, Kolstrup, Kolstrup, Kolstrup, Koster, Koster, Koster, Lea, Lea, Lea, Lewkowicz, MacDonald, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Mackay, Mark D. Bateman, Melnikov, Murton, Murton, Murton, Péwé, Rampton, Ritchie, Sher, Sletten, Taylor, Van der Hammen, Vandenberghe, Vasil'chuk, Worsley, Yershov   +57 more
core   +1 more source