Results 61 to 70 of about 182,437 (357)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Synoptic climate change as a driver of late Quaternary glaciations in the mid-latitudes of the Southern Hemisphere [PDF]
Climate of the Past, 2006 The relative timing of late Quaternary glacial advances in mid-latitude (40-55° S) mountain belts of the Southern Hemisphere (SH) has become a critical focus in the debate on global climate teleconnections.
H. Rother, J. Shulmeister
doaj
Steppes, savannahs, forests and phytodiversity reservoirs during the Pleistocene in the Iberian Peninsula [PDF]
, 2010 A palaeobotanical analysis of the Pleistocene floras and vegetation in the Iberian Peninsula shows the existence of patched landscapes with Pinus woodlands, deciduous and mixed forests, parklands (savannah-like), shrublands, steppes and grasslands ...
Agustí +259 more
core +3 more sources
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Zephyrus, 2013 Today, the Late Glacial interstadials Bølling and Allerød, originally defined in northern Europe, are often applied as chronozones in different palaeoclimate contexts across the Northern Hemisphere. The scientific community in both palaeoclimate research
Olaf JÖRIS, Esteban ÁLVAREZ FERNÁNDEZ
doaj
Les Nouvelles de l’Archéologie, 2015 This collective project of research, which started in 2009, is dedicated to hunter-gatherers societies in Paris Basin from the fourteenth millenium cal BC until the sixth millenium cal BC, i.e during the Late Glacial and the beginning of the Post Glacial.
Boris Valentin
doaj +1 more source
Glacial events in Carboniferous sequences from Paganzo and Río Blanco Basins (Northwest Argentina): Palynology and depositional setting [PDF]
, 2010 The age and depositional setting of two glacial events recognized in the western basins of Argentina are discussed in this paper. The older one corresponds to diamictites identified in the upper member of the Cortaderas Formation (Visean, Río Blanco ...
Césari, S.N. +2 more
core +3 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
A uniform isotopic and chemical signature of dust exported from Patagonia: Rock sources and occurrence in southern environments [PDF]
, 2007 Patagonia is considered to be the most important source of dust from South America that is deposited in surrounding areas, and we present here a systematic Sr and Nd isotopic study of sediment currently being exported.
Brunet, Frédéric +3 more
core +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source