Results 61 to 70 of about 178,686 (262)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Zephyrus, 2013 Today, the Late Glacial interstadials Bølling and Allerød, originally defined in northern Europe, are often applied as chronozones in different palaeoclimate contexts across the Northern Hemisphere. The scientific community in both palaeoclimate research
Olaf JÖRIS, Esteban ÁLVAREZ FERNÁNDEZ
doaj
Les Nouvelles de l’Archéologie, 2015 This collective project of research, which started in 2009, is dedicated to hunter-gatherers societies in Paris Basin from the fourteenth millenium cal BC until the sixth millenium cal BC, i.e during the Late Glacial and the beginning of the Post Glacial.
Boris Valentin
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Application data base paleogeographic Kola peninsula «Q-KOLA» in paleolimnological research
Transactions of the Karelian Research Centre of the Russian Academy of Sciences, 2015 The paleogeographic database “Q-KOLA” was created to systematize, statistically analyze and visualize information about the history of the natural ecosystems of the Kola Peninsula in the Late Glacial and Holocene. The database can be used in limnological
Ivan Grekov, Dmitry Subetto
doaj +1 more source
Three hundred eighty thousand year long stable isotope and faunal records from the Red Sea : influence of global sea level change on hydrography [PDF]
, 1996 Stable isotope and faunal records from the central Red Sea show high-amplitude oscillations for the past 380,000 years. Positive δ18O anomalies indicate periods of significant salt buildup during periods of lowered sea level when water mass exchange with
Ahuva Almogi-Labin +53 more
core +2 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Effects of Pleistocene climate changes on species ranges and evolutionary processes in the Neotropical Atlantic Forest [PDF]
, 2016 The effects of global glaciations on the distribution of organisms is an essential element of many diversification models. However, the empirical evidence supporting this idea is mixed, in particular with respect to explaining tropical forest evolution ...
Cabanne, Gustavo Sebastián +6 more
core +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source