Results 101 to 110 of about 178,775 (272)

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

Of Boyling and Seething: A Re-evaluation of the Common Cooking Terms in Connection with Brewing

open access: yesEXARC Journal, 2018
Modern chemistry provides us with a deeper understanding of fermentation, but that does not necessarily translate into an easier interpretation of medieval recipes.
Susan Verberg
doaj  

Islamic Law, Western European Law and the Roots of Middle East's Long Divergence: a Comparative Empirical Investigation (800-1600) [PDF]

open access: yesarXiv
We examine the contribution of Islamic legal institutions to the comparative economic decline of the Middle East behind Latin Europe, which can be observed since the late Middle Ages. To this end, we explore whether the sacralization of Islamic law and its focus on the Sharia as supreme, sacred and unchangeable legal text, which reached its culmination
arxiv  

Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value

open access: yesMolecular Oncology, EarlyView.
The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song   +13 more
wiley   +1 more source

Conference Review: EXARC at the International Congress on Medieval Studies in Kalamazoo, Michigan (USA)

open access: yesEXARC Journal, 2017
The International Congress on Medieval Studies is held at Western Michigan University in Kalamazoo each May. Now in its 52nd year, ICMS draws around 3,000 people attending approximately 575 sessions of papers, panel discussions, round tables, workshops ...
Neil Peterson, Karen Davidson
doaj  

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Searching for Dubh: Experiments in Black Dyes Pre 15th Century in Ireland and Scotland

open access: yesEXARC Journal
This paper explores sources of black dyes in Ireland and Scotland prior to 1500, in order to better understand the extent to which they were used and the hues that can be produced.
Ashley Stillwell-Hasan
doaj  

Experimental Analysis of Metal Points from Quattro Macine: Reproduction and Interpretation

open access: yesEXARC Journal, 2019
This paper relates to a study of experimental archaeology, executed by Ruben Cataldo, about the forging methods used to produce some replicas of two metal points found during the archaeological excavations carried out between 1992 and 1996 by the ...
Ruben Cataldo
doaj  

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