Results 61 to 70 of about 7,392,995 (289)

Sept millénaires d’exploitation du sel en Franche-Comté. Les salines de Salins-les-Bains

Archéopages, 2011
The salt works of Salins-Les-Bains in Franche-Comté are among UNESCO’s World Heritage Sites. Their exploitation at Salins-Les-Bains itself is documented from only the 8th century AD onwards.
Philippe Mairot
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Gebelein Region in the Third Intermediate and Late Periods

Études et Travaux (Institute des Cultures Méditerranéennes et Orientales de l'Académie Polonaise des Sciences)
While relatively much is known of Gebelein in the second and third millennia BCE, as well as the Ptolemaic times, the role of the town of Per-Hathor and its surrounding in the Third Intermediate (c. 1076–747 BCE) and Late (c.
Wojciech Ejsmond, Marta Kaczanowicz
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Change in Northumbria : was Aldfrith of Northumbria's reign a period of innovation or did it merely reflect the development of processes already underway in the late seventh century? [PDF]

, 2015
This thesis looks at a period of Northumbrian history when the king was a part Irish, Iona trained scholar. Some have suggested that Aldfrith was assisted to the kingship by the northern victors of the battle of Nechtansmere. It examines processes in the
Watson, W. Graham
core   +2 more sources

UPLC-QE-MS Analysis of the Differences in Milk Metabolites from Guanzhong Dairy Goats at the Peak and Late Lactation Stages [PDF]

Shipin Kexue
In order to explore the dynamic changes of metabolites in goat milk during different lactation periods, the differential metabolites in milk from Guanzhong dairy goats at the peak and late lactation stages were investigated by ultra-high performance ...
YU Mengqi, YUAN Yuxin, CHEN Lu, SHARI Akang, REN Xinyang, QU Yingxin, LI Guang
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

OSTEOFITOSIS VERTEBRAL EN POBLACIONES PREHISPÁNICAS DE SAN PEDRO DE ATACAMA, NORTE DE CHILE

Estudios Atacameños
Se estudió la osteofitosis vertebral como indicador de estrés físico en grupos humanos prehistóricos de San Pedro de Atacama, durante los períodos Medio (400 DC - 1000 DC) e Intermedio Tardío (1000 DC - 1450 DC).
Rocío López-Barrales, Mark Hubbe, Eugenio Aspillaga, Walter A Neves, Hermann M Niemeyer   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source