Results 81 to 90 of about 1,224,700 (310)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Archéopages, 2012 The reliefs that used to adorn the entrance of the Soviet pavilion at the International Exposition held in Paris in 1937 were rediscovered in 2004 in one of the ice-houses of the castle of Baillet-en-France (Val-d’Oise).
Marie Vacher
doaj +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
La production sucrière à Marseille. Apports archéologiques à la question
Archéopages, 2011 One would expect that sugar produced on French soil would bring significant benefits and independence from sugar-producing countries. Some sources mention that Marseille possessed sugar refineries from the 16th century onwards and their number may have ...
Véronique Abel
doaj +1 more source
The dorian dilemma: Problems and interpretations of social change in late Helladic iii c and dark age Greece with reference to the archaeological and literary evidence [PDF]
, 1986 Early Greek history, i.e. Greek history prior to about the mid-sixth century B.C., is as obscure to modern historians as it was to the ancient ones. One of the events which has been mentioned and described by ancient sources and is supposed to have ...
Dierckx, Heidi
core
Elite Burials with Bohemian Garnets in Vendel Period Sweden
, 2023 This paper is a short note on two elite burilas from present day Sweden. Dated to the Vendel period, i.e. the equivalent of the Merovingian period in Swedish historical writing, these two burials contain the only known examples of Bohemian garnets in the
Hedenstierna-Jonson, Charlotte, +1 more
core
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
La part d’héritage : le cas des céramiques pérennes d’époque moderne et contemporaine
Archéopages, 2012 The analysis of pottery of the modern period, whose methodology was established from the 1980s onwards, has recently benefited from much new input. The increase in excavations in advance of development over the last two decades, in post-medieval contexts
Alban Horry
doaj +1 more source