Results 81 to 90 of about 7,392,995 (289)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The Decline and Fall of the Mithraea of Rome [PDF]
, 2016 The end of paganism has traditionally been explained as a result of the rise of Christianity. In recent scholarship, the romantic image of an epic battle between pagans and Christians in Late Antiquity has been significantly altered and corrected ...
Schuddeboom, F.L. +3 more
core +2 more sources
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
How Late Can First Births Be Postponed? Some Illustrative Population-level Calculations [PDF]
I shift, stretch, and transform the observed cohort age-schedule of first birth for Danish women born in 1963 to see how late the mean age at first birth could plausibly shift.
Joshua R. Goldstein
core
Archéopages, 2012 The reliefs that used to adorn the entrance of the Soviet pavilion at the International Exposition held in Paris in 1937 were rediscovered in 2004 in one of the ice-houses of the castle of Baillet-en-France (Val-d’Oise).
Marie Vacher
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
La production sucrière à Marseille. Apports archéologiques à la question
Archéopages, 2011 One would expect that sugar produced on French soil would bring significant benefits and independence from sugar-producing countries. Some sources mention that Marseille possessed sugar refineries from the 16th century onwards and their number may have ...
Véronique Abel
doaj +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source