Latent HIV Reservoirs in the Central Nervous System: Mechanisms, Barriers, and Therapeutic Approaches. [PDF]
ACS Infect DisMatthew Y +4 more
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Block-and-Lock Approaches for HIV Cure: Mechanistic Insights, Challenges, and Emerging Role of CPSF6. [PDF]
Int J Mol SciTolomeo M, Cascio A.
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Astragalus polysaccharide promotes latent HIV-1 reactivation via exosome-mediated modulation of the PI3K/AKT/NF-κB axis. [PDF]
Extracell Vesicles Circ Nucl AcidsXu F +6 more
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Journal of the American Chemical SocietyTigliane diterpenoids possess exceptionally complex structures comprising common 5/7/6/3-membered ABCD-rings and disparate oxygen functionalities. While tiglianes display a wide range of biological activities, compounds with HIV latency-reversing activity can eliminate viral reservoirs, thereby serving as promising leads for new anti-HIV agents. Herein,
Ayumu Watanabe +9 more
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Advances in structure-activity relationships of HDAC inhibitors as HIV latency-reversing agents
Expert Opinion on Drug DiscoveryHIV-infected cells may rebound due to the existence of the silent HIV-infected memory CD4+ T cells (HIV latency). This HIV latency makes the disease almost incurable. In latency, the integrated proviral DNA of HIV is transcriptionally silenced partly due to the activity of histone deacetylases (HDACs).
Samima Khatun +2 more
exaly +3 more sources
Latency-reversing agents: where are we now? [PDF]
Current Opinion in HIV and AIDSPurpose of review Despite effective antiretroviral therapy (ART), HIV-1 persists in latently infected cells that evade host immunity and can resume viral production upon treatment interruption. To address this challenge, the “shock and kill” strategy aims to use latency-reversing agents (LRAs) to reactivate HIV ...
Bendoumou, Maryam, Van Lint, Carine
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HIV latency reversal agents: A potential path for functional cure?
European Journal of Medicinal Chemistry, 2021Despite the advances in Human Immunodeficiency Virus (HIV) treatment, the cure for all HIV patients still poses a major challenge, which needs to be surpassed in the coming years. Among the strategies pursuing this aim, the 'kick-and-kill' approach, which involves the reactivation and elimination of a latent HIV reservoir that resides in some CD4+ T ...
Juliana Romano Lopes +2 more
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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing
Journal of Visualized Experiments, 2019HIV remains incurable due to the existence of a reservoir of cells that harbors stable and latent form of the virus, which stays invisible to the immune system and is not targeted by the current antiretroviral therapy (cART). Transcription and splicing have been shown to reinforce HIV-1 latency in resting CD4+ T cells. Reversal of latency by the use of
Georges, Khoury, Damian F J, Purcell
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Discovery of Potent DAG-Lactone Derivatives as HIV Latency Reversing Agents
ACS Infectious DiseasesToward human immunodeficiency virus type-1 (HIV-1) cure, cells latently infected with HIV-1 must be eliminated from people living with HIV-1. We previously developed a protein kinase C (PKC) activator, diacylglycerol (DAG)-lactone derivative 3, with high HIV-1 latency-reversing activity, based on YSE028 (2) as a lead compound and found that the ...
Takahiro Ishii +12 more
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THE CURRENT STATUS OF LATENCY REVERSING AGENTS
2019info:eu-repo/semantics ...
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