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Shocking HIV-1 with immunomodulatory latency reversing agents [PDF]

open access: yesSeminars in Immunology, 2021
The "shock-and-kill" strategy is one of the most explored HIV-1 cure approaches to eliminate latent virus. This strategy is based on HIV-1 reactivation using latency reversing agents (LRAs) to reactivate latent proviruses (the "shock" phase) and to ...
Gilles Darcis   +2 more
exaly   +2 more sources

The Current Status of Latency Reversing Agents for HIV-1 Remission

open access: yesAnnual Review of Virology, 2021
Combinatory antiretroviral therapy (cART) reduces human immunodeficiency virus type 1 (HIV-1) replication but is not curative because cART interruption almost invariably leads to a rapid rebound of viremia due to the persistence of stable HIV-1-infected ...
Gilles Darcis, Anthony Rodari
exaly   +2 more sources
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Synthesis and Biological Evaluation of Simplified Ansellone Analogues with Lipophilic Side Chains as HIV Latency-Reversing Agents

Chemistry - A European Journal, 2023
Kenichi Murai   +2 more
exaly  

Advances in structure-activity relationships of HDAC inhibitors as HIV latency-reversing agents

Expert Opinion on Drug Discovery
Shovanlal Gayen   +2 more
exaly  

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