Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure [PDF]
Molecular Therapy - Nucleic Acids, 2021 The advent of antiretroviral therapy almost 25 years ago has transformed HIV-1 infection into a manageable chronic condition, albeit still incurable. The inability of the treatment regimen to eliminate latently infected cells that harbor the virus in an ...
Saikat Boliar, David G Russell
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Implications of HIV-1 Nef for “Shock and Kill” Strategies to Eliminate Latent Viral Reservoirs [PDF]
Viruses, 2018 Finding a cure for HIV is challenging because the virus is able to integrate itself into the host cell genome and establish a silent state, called latency, allowing it to evade antiviral drugs and the immune system.
Mark A. Brockman, Xiaomei T Kuang
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Shock and kill, but don't miss the target [PDF]
EBioMedicine, 2020 Georges Herbein
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Prime, shock and kill: BCL-2 inhibition for HIV cure [PDF]
Frontiers in Immunology, 2022 While modern HIV therapy can effectively suppress viral replication, the persistence of the latent reservoir posits the greatest hurdle to complete cure.
Aswath P. Chandrasekar +3 more
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The Effect of Latency Reversal Agents on Primary CD8+ T Cells: Implications for Shock and Kill Strategies for Human Immunodeficiency Virus Eradication [PDF]
EBioMedicine, 2016 Shock and kill strategies involving the use of small molecules to induce viral transcription in resting CD4+ T cells (shock) followed by immune mediated clearance of the reactivated cells (kill), have been proposed as a method of eliminating latently ...
Christopher W Pohlmeyer +2 more
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A commentary of “‘Shock and Kill’ of Latent HIV” : 10 remarkable discoveries from 2020 in Nature [PDF]
Fundamental Research, 2022 HIV, the virus that causes acquired immunodeficiency syndrome (AIDS), can integrate into the genome of host cells and form latent reservoirs, making it undetectable by the immune system.
Yangyang Li, Linqi Zhang
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A scalable workflow to test “shock and kill” therapeutic approaches against the HIV-1 latent reservoir in blood cells ex vivo [PDF]
STAR Protocols, 2023 Summary: Integrated HIV-1 DNA persists in cells of people living with HIV during antiretroviral treatment, but its quantification is hindered by its rarity.
Francesco Andrea Procopio +2 more
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Dynamic modulation of the non-canonical NF-κB signaling pathway for HIV shock and kill [PDF]
Frontiers in Cellular and Infection MicrobiologyHIV cure still remains an elusive target. The “Shock and Kill” strategy which aims to reactivate HIV from latently infected cells and subsequently kill them through virally induced apoptosis or immune mediated clearance, is the subject of widespread ...
Aswath P. Chandrasekar +5 more
doaj +2 more sources
<i>Euphorbia kansui</i> for latent virus reactivation in people living with HIV on suppressive antiretroviral therapy: A phase 1b/2a clinical trial. [PDF]
Journal of Virus EradicationBackground: The ‘Shock and Kill’ strategy is pivotal in the quest for an HIV/AIDS cure. Our study explores Euphorbia kansui (Kansui), a traditional Chinese medicine, for its potential to reverse HIV latency while rigorously assessing safety.
Jingna Xun +23 more
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Histone Deacetylase Inhibitors (HDACis) as Latency-Reversing Agents in HIV Cure Strategies: Chemistry, Selectivity, and Clinical Perspective [PDF]
VirusesLatently infected resting CD4+ T cells represent the principal barrier to HIV eradication. Their immunological quiescence renders them invisible to combination antiretroviral therapy (cART) and host immune surveillance, sustaining a reservoir that ...
Hanan Almolhim
doaj +2 more sources