Block-And-Lock Strategies to Cure HIV Infection [PDF]
Viruses, 2020 Today HIV infection cannot be cured due to the presence of a reservoir of latently infected cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is considered as the major barrier for an HIV cure.
Gerlinde Vansant +3 more
doaj +8 more sources
Block-And-Lock: New Horizons for a Cure for HIV-1 [PDF]
Viruses, 2020 HIV-1/AIDS remains a global public health problem. The world health organization (WHO) reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which only 67% were accessing antiretroviral therapy (ART).
Ines Moranguinho, Susana T. Valente
doaj +8 more sources
Block and Lock HIV Cure Strategies to Control the Latent Reservoir [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 The HIV latent reservoir represents the major challenge to cure development. Residing in resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary sites such as the brain, the latent reservoir is not eliminated by ART ...
Chantelle L. Ahlenstiel +5 more
doaj +8 more sources
In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment [PDF]
Cell Reports, 2017 HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a “block-and-lock” functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA).
Cari F. Kessing +11 more
doaj +6 more sources
BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription [PDF]
Nature CommunicationsThe persistence of HIV-1 in a latent state within long-lived immune cells remains a major barrier to a cure for HIV-1 infection. The “block-and-lock” strategy aims to silence the HIV-1 provirus permanently using latency promoting agents (LPAs).
Eline Pellaers +9 more
doaj +3 more sources
The Block-and-Lock Strategy for Human Immunodeficiency Virus Cure: Lessons Learned from Didehydro-Cortistatin A. [PDF]
Journal of Infectious Diseases, 2021 Susana T Valente
exaly +2 more sources
The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency [PDF]
Microbiology SpectrumHIV integration is targeted toward active transcription units through the interaction of HIV integrase with the cellular co-factor LEDGF/p75. LEDGINs, small molecule inhibitors of this interaction, reduce HIV-1 integration and retarget residual ...
Anne Bruggemans +5 more
doaj +2 more sources
Toward a Functional Cure for HIV-1 Infection: The Block and Lock Therapeutic Approach
Frontiers in Virology, 2022 The persistence of latent, replication-competent HIV-1 proviruses in resting CD4+ T cells, and other cellular reservoirs, represents a major barrier to a cure.
Benni Vargas, Nicolas Sluis-Cremer
doaj +1 more source
HIV Latency and Nanomedicine Strategies for Anti-HIV Treatment and Eradication
Biomedicines, 2023 Antiretrovirals (ARVs) reduce Human Immunodeficiency Virus (HIV) loads to undetectable levels in infected patients. However, HIV can persist throughout the body in cellular reservoirs partly due to the inability of some ARVs to cross anatomical barriers ...
Mickensone Andre +2 more
doaj +1 more source
Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure
Viruses, 2023 Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing that control of ...
Natasha N. Duggan +3 more
doaj +1 more source