Block-And-Lock Strategies to Cure HIV Infection [PDF]
Viruses, 2020 Today HIV infection cannot be cured due to the presence of a reservoir of latently infected cells inducing a viral rebound upon treatment interruption. Hence, the latent reservoir is considered as the major barrier for an HIV cure.
Gerlinde Vansant +3 more
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Block-And-Lock: New Horizons for a Cure for HIV-1 [PDF]
Viruses, 2020 HIV-1/AIDS remains a global public health problem. The world health organization (WHO) reported at the end of 2019 that 38 million people were living with HIV-1 worldwide, of which only 67% were accessing antiretroviral therapy (ART).
Ines Moranguinho, Susana T. Valente
doaj +4 more sources
In Vivo Suppression of HIV Rebound by Didehydro-Cortistatin A, a “Block-and-Lock” Strategy for HIV-1 Treatment [PDF]
Cell Reports, 2017 HIV-1 Tat activates viral transcription and limited Tat transactivation correlates with latency establishment. We postulated a “block-and-lock” functional cure approach based on properties of the Tat inhibitor didehydro-Cortistatin A (dCA).
Cari F. Kessing +11 more
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Block and Lock HIV Cure Strategies to Control the Latent Reservoir [PDF]
Frontiers in Cellular and Infection Microbiology, 2020 The HIV latent reservoir represents the major challenge to cure development. Residing in resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary sites such as the brain, the latent reservoir is not eliminated by ART ...
Chantelle L. Ahlenstiel +5 more
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Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection [PDF]
Viruses, 2018 Despite significant improvements in therapy, the HIV/AIDS pandemic remains an important threat to public health. Current treatments fail to eradicate HIV as proviral DNA persists in long-living cellular reservoirs, leading to viral rebound whenever ...
Zeger Debyser +4 more
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BRD4 modulator ZL0580 and LEDGINs additively block and lock HIV-1 transcription [PDF]
Nature CommunicationsThe persistence of HIV-1 in a latent state within long-lived immune cells remains a major barrier to a cure for HIV-1 infection. The “block-and-lock” strategy aims to silence the HIV-1 provirus permanently using latency promoting agents (LPAs).
Eline Pellaers +9 more
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The Block-and-Lock Strategy for Human Immunodeficiency Virus Cure: Lessons Learned from Didehydro-Cortistatin A. [PDF]
Journal of Infectious Diseases, 2021 Susana T Valente
exaly +2 more sources
The LEDGIN GS-9822 inhibits HIV-2 infection and enhances HIV-2 latency [PDF]
Microbiology SpectrumHIV integration is targeted toward active transcription units through the interaction of HIV integrase with the cellular co-factor LEDGF/p75. LEDGINs, small molecule inhibitors of this interaction, reduce HIV-1 integration and retarget residual ...
Anne Bruggemans +5 more
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Toward a Functional Cure for HIV-1 Infection: The Block and Lock Therapeutic Approach
Frontiers in Virology, 2022 The persistence of latent, replication-competent HIV-1 proviruses in resting CD4+ T cells, and other cellular reservoirs, represents a major barrier to a cure.
Benni Vargas, Nicolas Sluis-Cremer
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Fighting HIV-1 Persistence: At the Crossroads of “Shoc-K and B-Lock”
Pathogens, 2021 Despite the success of highly active antiretroviral therapy (HAART), integrated HIV-1 proviral DNA cannot be eradicated from an infected individual. HAART is not able to eliminate latently infected cells that remain invisible to the immune system.
Chiara Acchioni +5 more
doaj +1 more source