The impact of the complete atrioventricular block on in-hospital and long-term mortality in patients treated with primary percutaneous coronary intervention [PDF]
Vojnosanitetski Pregled, 2023 Background/Aim. The prognostic impact of complete atrioventricular (AV) block on the long-term prognosis of patients with ST-elevation myocardial infarction (STEMI) has not been fully determined.
Savić Lidija +4 more
doaj +1 more source
Repression of HIV-1 reactivation mediated by CRISPR/dCas9-KRAB in lymphoid and myeloid cell models
Retrovirology, 2022 Background Despite antiretroviral treatment efficacy, it does not lead to the complete eradication of HIV infection. Consequently, reactivation of the virus from latently infected cell reservoirs is a major challenge toward cure efforts.
Lendel Correia da Costa +5 more
doaj +1 more source
HIV Latency and Nanomedicine Strategies for Anti-HIV Treatment and Eradication
Biomedicines, 2023 Antiretrovirals (ARVs) reduce Human Immunodeficiency Virus (HIV) loads to undetectable levels in infected patients. However, HIV can persist throughout the body in cellular reservoirs partly due to the inability of some ARVs to cross anatomical barriers ...
Mickensone Andre +2 more
doaj +1 more source
Experimental Investigation on the Torsion-Shear Behaviour at the Interfaces of Interlocking Masonry Block Assemblages [PDF]
, 2021 This paper presents an experimental investigation on the initial shear (cohesion) and torsion-shear strengths at the interface of an interlocking masonry block. An interlocking block is a rigid unit with locks avoiding the block to slide.
C. Ceraldi +11 more
core +1 more source
Torsion-shear behaviour at the interfaces of rigid interlocking blocks in masonry assemblages:Experimental investigation and analytical approaches [PDF]
, 2021 Increasing interest has recently been devoted to interlocking blocks/interfaces capable to enhance the sliding resistance of masonry joints to external forces.
Bagi, Katalin +4 more
core +2 more sources
The role of miR-29a in HIV-1 replication and latency
Journal of Virus Eradication, 2017 The development of an effective HIV-1 eradication strategy relies upon a clear understanding of the cellular mechanisms involved in HIV-1 latency. Among such cellular processes, microRNA activities affect HIV-1 production by regulating viral transcripts ...
Giacomo Frattari +2 more
doaj +1 more source
Viruses, 2020 Human immunodeficiency virus (HIV-1) indefinitely persists, despite effective antiretroviral therapy (ART), within a small pool of latently infected cells. These cells often display markers of immunologic memory and harbor both replication-competent and -
Roland Schwarzer +2 more
doaj +1 more source
Antimicrobial Agents and Chemotherapy, 2023 Abstract Antiretroviral therapy is not a cure for HIV-1 as viral rebound ensues immediately following discontinuation. The block and lock therapeutic strategy seeks to enforce proviral latency and durably suppress viremic reemergence in the absence of antiretroviral therapy. Transcriptional Cyclin Dependent Kinase activity regulates LTR
Riley M. Horvath +2 more
openaire +2 more sources
Breaking the Silence: Regulation of HIV Transcription and Latency on the Road to a Cure
Viruses, 2023 Antiretroviral therapy (ART) has brought the HIV/AIDS epidemic under control, but a curative strategy for viral eradication is still needed. The cessation of ART results in rapid viral rebound from latently infected CD4+ T cells, showing that control of ...
Natasha N. Duggan +3 more
doaj +1 more source
Sulforaphane prevents the reactivation of HIV-1 by suppressing NFκB signaling
Journal of Virus Eradication, 2023 Despite more than 20 years of combination antiretroviral therapy (cART), complete eradication of HIV remains a daunting task. While cART has been very effective in limiting new cycles of infection and keeping viral load below detectable levels with ...
Imran Jamal +5 more
doaj +1 more source