Results 1 to 10 of about 412,466 (343)

Toll-Like Receptor 7 Agonist RG7854 Mediates Therapeutic Efficacy and Seroconversion in Woodchucks With Chronic Hepatitis B

Frontiers in Immunology, 2022
Conventional treatment of chronic hepatitis B (CHB) is rarely curative due to the immunotolerant status of patients. RG7854 is an oral double prodrug of a toll-like receptor 7 (TLR7) agonist that is developed for the treatment of CHB.
Steffen Wildum, Kyle E. Korolowicz, Manasa Suresh, Guido Steiner, Lue Dai, Bin Li, Changsuek Yon, Maria Cristina De Vera Mudry, Franziska Regenass-Lechner, Xu Huang, Xupeng Hong, Marta G. Murreddu, Bhaskar V. Kallakury, John A. T. Young, Stephan Menne   +14 more
doaj   +1 more source

Animal models of functional HIV cure [PDF]

Retrovirology, 2012
Developing new therapeutic strategies to achieve a functional cure for HIV infection is a central objective for contemporary AIDS research. A key obstacle towards a functional cure for HIV/AIDS is the paucity of information regarding the establishment and maintenance of the persistent reservoirs of latently HIV-infected cells which support the rapid ...
openaire   +1 more source

Developing Combined HIV Vaccine Strategies for a Functional Cure [PDF]

Vaccines, 2013
Increasing numbers of HIV-infected individuals have access to potent antiretroviral drugs that control viral replication and decrease the risk of transmission. However, there is no cure for HIV and new strategies have to be developed to reach an eradication of the virus or a natural control of viral replication in the absence of drugs (functional cure).
Noto, Alessandra, Trautmann, Lydie
openaire   +2 more sources

Persistent risk for new, subsequent new and recurrent hepatocellular carcinoma despite successful anti-hepatitis B virus therapy and tumor ablation: The need for hepatitis B virus cure. [PDF]

, 2019
Hepatitis B virus (HBV) is one of the most significant hepatocarcinogens. The ultimate goal of anti-HBV treatment is to prevent the development of hepatocellular carcinoma (HCC).
Coben, Robert M., Conn, Mitchell I., DiMarino, Anthony J., Hann, Hie-Won, Kroop, Howard, Martin, Aaron, Prieto, Jorge, Shinn, Brianna J.   +7 more
core   +1 more source

Cure kinetics of ring-opening metathesis polymerization of dicyclopentadiene [PDF]

, 2002
The cure kinetics of polydicyclopentadiene (pDCPD) prepared by ring-opening metathesis polymerization with three different concentrations of Grubbs' catalyst was examined using differential scanning calirimetry (DSC).
Kessler, Michael R., White, Scott R.
core   +1 more source

Emerging PCR-based techniques to study HIV-1 reservoir persistence [PDF]

, 2020
While current antiretroviral therapies are able to halt HIV-1 progression, they are not curative, as an interruption of treatment usually leads to viral rebound.
Cole, Basiel, Lambrechts, Laurens, Rutsaert, Sofie, Trypsteen, Wim, Vandekerckhove, Linos   +4 more
core   +2 more sources

Safety and durability of AGT103-T autologous T cell therapy for HIV infection in a Phase 1 trial

Frontiers in Medicine, 2022
The cell and gene therapy product AGT103-T was designed to restore the Gag-specific CD4+ T cell response in persons with chronic HIV disease who are receiving antiretroviral therapy.
Nidal Muvarak, Haishan Li, Tyler Lahusen, Jeffrey A. Galvin, Princy N. Kumar, C. David Pauza, José Bordon   +6 more
doaj   +1 more source

Interventions for neurocognitive dysfunction [PDF]

, 2017
Purpose of review: To evaluate current barriers to HIV cure strategies and interventions for neurocognitive dysfunction with a particular focus on recent advancements over the last three years. Recent findings: Optimal anti-retroviral therapy (ART) poses
Brew, B, Ellero, J, Lubomski, M
core   +2 more sources

Circulating HBsAg-specific B cells are partially rescued in chronically HBV-infected patients with functional cure

Emerging Microbes and Infections
It is well established that humoral immunity targeting hepatitis B virus surface antigen (HBsAg) plays a critical role in viral clearance and clinical cure.
Shuqin Gu, Libo Tang, Ling Guo, Chunxiu Zhong, Xin Fu, Guofu Ye, Shihong Zhong, Xiaoyi Li, Chunhua Wen, Yang Zhou, Jinling Wei, Haitao Chen, Nikolai Novikov, Simon P. Fletcher, M. Anthony Moody, Jinlin Hou, Yongyin Li   +16 more
doaj   +1 more source

Interferon-α Subtypes As an Adjunct Therapeutic Approach for Human Immunodeficiency Virus Functional Cure

Frontiers in Immunology, 2018
Human immunodeficiency virus (HIV) establishes life-long latency in infected individuals. Although highly active antiretroviral therapy (HAART) has had a significant impact on the course of HIV infection leading to a better long-term outcome, the pool of
Jeffy George, Joseph J. Mattapallil
doaj   +1 more source