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HIV controllers: hope for a functional cure [PDF]

Frontiers in Immunology
Elite controllers (ECs) and post-treatment controllers (PTCs) represent important models for achieving a functional cure for HIV. This review synthesizes findings from immunological, genetic, and virological studies to compare the mechanisms underlying ...
Zhuoya Deng, Zhuoya Deng, Hongxia Yan, Hongxia Yan, Olivier Lambotte, Christiane Moog, Christiane Moog, Bin Su, Bin Su, Bin Su   +9 more
doaj   +4 more sources

Evolution of therapeutic paradigms in Hodgkin lymphoma: from “cure-oriented” to “functional cure” [PDF]

Frontiers in Oncology
Hodgkin lymphoma (HL) is a B-cell–derived hematologic malignancy originating from germinal centre B cells. Owing to its remarkable sensitivity to chemotherapy and radiotherapy, HL has become one of the most curable adult malignancies.
Chengqian Chen, Wei Guo, Xiaoyu Song, Xin Wan, Zhaoxia Li, Haotian Wang, Ou Bai   +6 more
doaj   +2 more sources

Re-examining the HIV ‘functional cure’ oxymoron: Time for precise terminology?

Journal of Virus Eradication, 2020
For over a decade, the binary concepts of ‘sterilizing’ versus ‘functional’ cure have provided an organizing framework for the field of HIV cure-related research.
Karine Dubé, Loreen Willenberg, Lynda Dee, Laurie Sylla, Jeff Taylor, Christopher Roebuck, David Palm, Danielle Campbell, Luke Newton, Hursch Patel, Kelly E. Perry, John Kanazawa, Jo Gerrard, Brandon Brown, Parya Saberi, John A. Sauceda, Michael J. Peluso   +16 more
doaj   +3 more sources

Determinants of functional cure in interferon-treated chronic hepatitis B: a retrospective cohort analysis of HBsAg dynamics and clinical predictors

Frontiers in Cellular and Infection Microbiology
Background and ObjectivesFunctional cure of chronic hepatitis B (CHB) is the optimal goal of antiviral therapy. This study evaluates the functional cure rates in a large cohort treated with interferon (IFNα) and explores baseline predictors to optimize ...
Daqiong Zhou, Jianru Jia, Feng Zhao, Jiangyu Liu, Zichen Zhang, Zhenhuan Cao, Zhenhuan Cao   +6 more
doaj   +3 more sources

Toward Precise Risk Stratification after the Functional Cure of Chronic Hepatitis B [PDF]

The Korean Journal of Gastroenterology
Chronic hepatitis B remains a major global health challenge despite the advances in antiviral therapy. Although hepatitis B surface antigen (HBsAg) seroclearance is considered a functional cure, liver-related complications, particularly hepatocellular ...
Moon Haeng Hur
doaj   +2 more sources

Racing toward the future of chronic hepatitis B management: Achieving functional cure and enhancing hepatocellular carcinoma surveillance through precision medicine

Interdisciplinary Medicine
Hepatitis B virus (HBV) infection represents a significant global public health threat, often progressing to severe complications such as liver cirrhosis and hepatocellular carcinoma (HCC).
Yaru Shi, Rong Fan
doaj   +2 more sources

Attitudes of Men Who Have Sex With Men Toward HIV Functional Cure: Community-Based Study [PDF]

JMIR Formative Research
BackgroundInvestigation of community awareness of HIV functional cure has often been restricted to people living with HIV. An understanding of the attitudes of men who have sex with men (MSM) without HIV is important, as it contributes to the ...
Ngai Sze Wong, Sze Long Chung, Tsz Ho Kwan, Shui Shan Lee   +3 more
doaj   +2 more sources

Targeting the innate immune system in treating hepatitis B: prospects for functional cure [PDF]

Clinical and Molecular Hepatology
Chronic hepatitis B (CHB) infection remains a significant global public health concern. Functional cure, defined as hepatitis B surface antigen seroclearance with unquantifiable HBV DNA at 24 weeks off treatment, is a desirable endpoint in the treatment ...
Karen Cheuk-Ying Ho, Rex Wan-Hin Hui, Wai-Kay Seto, Man-Fung Yuen, Lung-Yi Mak   +4 more
doaj   +2 more sources

Functional molecular expression of nature killer cells correlated to HBsAg clearance in HBeAg-positive chronic hepatitis B patients during PEG-IFN α-2a therapy

Frontiers in Immunology, 2022
ObjectiveTo explore whether the frequencies and functional molecules expression of Natural Killer cells (NK cells) are related to hepatitis B surface antigen (HBsAg) disappearance in hepatitis B e envelope antigen (HBeAg)-positive patients with chronic ...
Weihua Cao, Weihua Cao, Huihui Lu, Huihui Lu, Luxue Zhang, Luxue Zhang, Shiyu Wang, Wen Deng, Tingting Jiang, Yanjie Lin, Liu Yang, Xiaoyue Bi, Yao Lu, Lu Zhang, Ge Shen, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Yao Xie, Yao Xie, Minghui Li, Minghui Li   +26 more
doaj   +1 more source

Patient acceptability of, and attitudes towards, hepatitis B cure research – A scoping review and identification of knowledge gaps

Journal of Virus Eradication, 2023
Functional cure, defined as durable loss of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA suppression off therapy, is an increasingly important goal in the treatment of chronic hepatitis B.
Neaka Mohtashemi, Karine Dubé, Chloe Thio, Sihyeong Song, Shail Patel, Jeremy Sugarman, Debika Bhattacharya   +6 more
doaj   +1 more source