Results 31 to 40 of about 155,433 (279)

In pursuit of a functional cure for follicular lymphoma. [PDF]

Hematology Am Soc Hematol Educ Program
Abstract We are now a quarter of a century after the transformative impact of rituximab in improving overall survival for patients with follicular lymphoma. With a burgeoning array of effective immunochemotherapy approaches, we can now frame many patients' expectations of longevity and a “functional cure,” with survival estimates for ...
Trotman J, Falconer J.
europepmc   +3 more sources

Transaminase Elevations during Treatment of Chronic Hepatitis B Infection: Safety Considerations and Role in Achieving Functional Cure

Viruses, 2021
While current therapies for chronic HBV infection work well to control viremia and stop the progression of liver disease, the preferred outcome of therapy is the restoration of immune control of HBV infection, allowing therapy to be removed while ...
Andrew Vaillant
doaj   +1 more source

PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

Cells, 2022
At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu, Yingtong Lin, Xiaoyun Zeng, Chan Yang, Siqin Duan, Liqiong Ding, Wanzhen Lu, Jian Lin, Xiaoyan Pan, Xiancai Ma, Shuwen Liu   +10 more
doaj   +1 more source

Broken symmetry in density-functional theory: Analysis and cure [PDF]

, 2004
We present a detailed analysis of the broken-symmetry mean-field solutions using a four-electron rectangular quantum dot as a model system. Comparisons of the density-functional theory predictions with the exact ones show that the symmetry-breaking ...
Puska, Martti J., Puska, M.J., Nieminen, R.M., Nieminen, Risto M., Harju, A., Räsänen, E., Saarikoski, H., Niemelä, K.   +7 more
core   +1 more source

The potential effect of HBV vaccination on off-treatment HBsAg reversion after interferon-induced HBsAg clearance

Human Vaccines & Immunotherapeutics, 2023
Off-treatment HBsAg reversion occurs in a considerable number of chronic hepatitis B(CHB) patients after IFN(interferon)-induced HBsAg clearance. HBV vaccination protects the general population against HBV infection.
Shaowen Jiang, Minghao Cai, Zhenglan Zhang, Cong Qian, Jiexiao Wang, Ziqiang Li, Qing Guo, Huijuan Zhou, Haiguang Xin, Wei Cai, Hui Wang, Simin Guo, Yan Huang, Qing Xie   +13 more
doaj   +1 more source

Chronicles of HBV and the Road to HBV Cure

Livers, 2023
Chronic hepatitis B remains a major public health concern and a leading cause of morbidity and mortality worldwide, specifically through its causative role in chronic liver disease and hepatocellular carcinoma.
Rukaiya Bashir Hamidu, Richard R. Hann, Hie-Won Hann   +2 more
doaj   +1 more source

Awareness of HBV Functional Cure and Attitude Toward Related Clinical Trials Among Patients with Chronic Hepatitis B in China

, 2023
Zhongping Duan,1 Jinling Dong,1 Ying Liu,2 Haiyang Zhou,2 Shuli Duan,2 Weihong Liu,3 Rico Liang,3 Yue Ding3 1Fourth Department of Hepatology Center, Beijing You’an Hospital, Capital Medical University, Beijing, People’s Republic of China; 2iGandan, the ...
Duan Z, Liu Y, Ding Y, Dong J, Duan S, Zhou H, Liu W, Liang R   +7 more
core  

Gene function in schistosomes: recent advances towards a cure [PDF]

Frontiers in Genetics, 2015
Schistosomes are human parasites distributed worldwide in tropical and sub-tropical latitudes, especially in developing countries and impoverished regions. These neglected tropical disease (NTD) pathogens causes debilitating illnesses, which include hepatosplenomegaly, hepatic fibrosis, haemorrhagic necrotic ulcerations in the intestinal mucosa ...
Arnon Dias Jurberg, Arnon Dias Jurberg, Paul J Brindley   +2 more
openaire   +5 more sources

Modulation of NKG2D expression in human CD8(+) T cells corresponding with tuberculosis drug cure. [PDF]

, 2012
BACKGROUND: Biomarkers predicting tuberculosis treatment response and cure would facilitate drug development. This study investigated expression patterns of the co-stimulation molecule NKG2D in human tuberculosis and treatment to determine its potential ...
Syeda S Hassan, Cho Jang-Eun, Hazel M. Dockrell, Fielding Katherine L., Cho, Jang-Eun, Katherine L. Fielding, Jang-Eun Cho, Muhammad Akram, Katherine L Fielding, Syeda S. Hassan¤a, Hassan, Syeda S, Akram Muhammad, Cliff, Jacqueline M, Jacqueline M. Cliff, Dockrell Hazel M., Fielding, Katherine L, Hazel M Dockrell, Akram, Muhammad, Dockrell, Hazel M, Jacqueline M Cliff, Hassan Syeda S., Cliff Jacqueline M.   +21 more
core   +1 more source

The scientific basis of combination therapy for chronic hepatitis B functional cure.

, 2023
Functional cure of chronic hepatitis B (CHB) - or hepatitis B surface antigen (HBsAg) loss after 24 weeks off therapy - is now the goal of treatment, but is rarely achieved with current therapy.
Lok, Anna S, Lim, Seng Gee, Baumert, Thomas F., Zoulim, Fabien, Boni, Carolina, Levrero, Massimo, Maini, Mala K, Gane, Ed, Terrault, Norah A   +8 more
core   +1 more source