Results 31 to 40 of about 412,466 (343)

Awareness of HIV functional cure and willingness in participating in related clinical trials: comparison between antiretroviral naïve and experienced men who have sex with men living with HIV

BMC Infectious Diseases, 2022
Background Human immunodeficiency virus (HIV) functional cure is a novel biomedical strategy characterized by sustained viral suppression without the need for life-long medications.
Tsz Ho Kwan, Chin Pok Chan, Ngai Sze Wong, Shui Shan Lee   +3 more
doaj   +1 more source

Re-examining the HIV ‘functional cure’ oxymoron: Time for precise terminology?

Journal of Virus Eradication, 2020
For over a decade, the binary concepts of ‘sterilizing’ versus ‘functional’ cure have provided an organizing framework for the field of HIV cure-related research.
Karine Dubé, Loreen Willenberg, Lynda Dee, Laurie Sylla, Jeff Taylor, Christopher Roebuck, David Palm, Danielle Campbell, Luke Newton, Hursch Patel, Kelly E. Perry, John Kanazawa, Jo Gerrard, Brandon Brown, Parya Saberi, John A. Sauceda, Michael J. Peluso   +16 more
doaj   +1 more source

Utility of novel viral and immune markers in predicting HBV treatment endpoints: A systematic review of treatment discontinuation studies

JHEP Reports, 2023
Background & Aims: Antivirals represent the mainstay of chronic hepatitis B treatment given their efficacy and tolerability, but rates of functional cure remain low during long-term therapy.
Georgia Zeng, Apostolos Koffas, Lung-Yi Mak, Upkar S. Gill, Patrick T.F. Kennedy   +4 more
doaj   +1 more source

Analysis of HBsAg Immunocomplexes and cccDNA Activity During and Persisting After NAP‐Based Therapy

Hepatology Communications, 2021
Therapy with nucleic acid polymers (NAPs), tenofovir disoproxil fumarate (TDF), and pegylated interferon (pegIFN) achieve high rates of HBsAg loss/seroconversion and functional cure in chronic hepatitis B virus (HBV) infection.
Michel Bazinet, Mark Anderson, Victor Pântea, Gheorghe Placinta, Iurie Moscalu, Valentin Cebotarescu, Lilia Cojuhari, Pavlina Jimbei, Liviu Iarovoi, Valentina Smesnoi, Tatina Musteata, Alina Jucov, Ulf Dittmer, Jeff Gersch, Vera Holzmayer, Mary Kuhns, Gavin Cloherty, Andrew Vaillant   +17 more
doaj   +1 more source

Functional dry-cured sausage production technology

IOP Conference Series: Earth and Environmental Science, 2022
Abstract One of the new directions for the modern meat processing industry is the production of functional meat products. The development of functional dry-cured sausages is of no small importance in the nutrition of the population, they have a high biological, nutritional value, gastronomic quality, presentation, have a positive effect ...
G S Dabuzova, P A Aligazieva, K M Kebedov, S K Omarov, I M Abdulaev   +4 more
openaire   +1 more source

Quantitatively Evaluate the Improvement of Functional Cure for the Quality of Life of Chronic Hepatitis B Cases: Evidence from a Cross-Sectional Study in China. [PDF]

Healthcare (Basel)
Zhang S, Gao Z, Li H, Kang Y, Fu L, Chen X, Xu X, Chen X, Zhuang H, Zheng H, Cui F.   +10 more
europepmc   +3 more sources

Transaminase Elevations during Treatment of Chronic Hepatitis B Infection: Safety Considerations and Role in Achieving Functional Cure

Viruses, 2021
While current therapies for chronic HBV infection work well to control viremia and stop the progression of liver disease, the preferred outcome of therapy is the restoration of immune control of HBV infection, allowing therapy to be removed while ...
Andrew Vaillant
doaj   +1 more source

PARP1 Might Substitute HSF1 to Reactivate Latent HIV-1 by Binding to Heat Shock Element

Cells, 2022
At present, the barrier to HIV-1 functional cure is the persistence of HIV-1 reservoirs. The “shock (reversing latency) and kill (antiretroviral therapy)” strategy sheds light on reducing or eliminating the latent reservoir of HIV-1. However, the current
Xinfeng Xu, Yingtong Lin, Xiaoyun Zeng, Chan Yang, Siqin Duan, Liqiong Ding, Wanzhen Lu, Jian Lin, Xiaoyan Pan, Xiancai Ma, Shuwen Liu   +10 more
doaj   +1 more source

Gribov horizon beyond the Landau gauge [PDF]

, 2013
Gribov and Zwanziger proposed a modification of Yang-Mills theory in order to cure the Gribov copy problem. We employ field-dependent BRST transformations to generalize the Gribov-Zwanziger model from the Landau gauge to general R_xi gauges.
Lavrov, Peter M., Lechtenfeld, Olaf
core   +3 more sources

Group-based trajectory modeling for declines in hepatitis B surface antigen over time accurately identifies chronic hepatitis B patients achieving functional cure: a single-center cohort study in China. [PDF]

Ann Med
Peng Y, Liu L, Wu X.
europepmc   +2 more sources